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Titolo:
EFFECTS OF SEISHIN-RENSHI-IN AND GYMNEMA-SYLVESTRE ON INSULIN-RESISTANCE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Autore:
TOMINAGA M; KIMURA M; SUGIYAMA K; ABE T; IGARASHI K; IGARASHI M; EGUCHI H; SEKIKAWA A; OGAWA A; MANAKA H; SASAKI H;
Indirizzi:
YAMAGATA UNIV,SCH MED,DEPT INTERNAL MED 3,2-2 IIDA NISHI 2 CHOME YAMAGATA 99023 JAPAN
Titolo Testata:
Diabetes research and clinical practice
fascicolo: 1, volume: 29, anno: 1995,
pagine: 11 - 17
SICI:
0168-8227(1995)29:1<11:EOSAGO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE; CONSTITUENTS; METABOLISM; CS-045; LEAVES; ACIDS;
Keywords:
SEISHIN-RENSHI-IN; GYMNEMA SYLVESTRE; INSULIN RESISTANCE; STREPTOZOTOCIN-INDUCED DIABETIC RATS; GLUCOSE CLAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Tominaga et al., "EFFECTS OF SEISHIN-RENSHI-IN AND GYMNEMA-SYLVESTRE ON INSULIN-RESISTANCE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS", Diabetes research and clinical practice, 29(1), 1995, pp. 11-17

Abstract

Although there is no concept of insulin resistance in traditional Kampo (Chinese) medicine and Indian medicine, we had the hypothesis that some drug in a mixture of crude drugs which was believed to amelioratediabetes mellitus may have had the effect of improving insulin resistance. To test this hypothesis, the effects of Seishin-renshi-in (Chinese medicine) and Gymnema sylvestre (Indian medicine) on the insulin resistance of streptozotocin-induced diabetic rats was studied by the glucose clamp technique. Oral administration of Seishin-renshi-in (800 mg/kg/day) with injections of a minimum dose of Ultralente insulin decreased urine volume and urinary glucose excretion during a 7-day treatment period and improved the insulin stimulated glucose uptake in peripheral tissues, as well as improving the insulin suppressed hepatic glucose output during glucose clamp. However, G. sylvestre (120 mg/kg/day) treatment did not improve insulin resistance. We conclude that Seishin-renshi-in, with a small dose of insulin, improved insulin resistance in streptozotocin-induced diabetic rats, but Gymnema sylvestre did not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:33:24