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Titolo:
AMYLOID PRECURSOR PROTEIN (APP) EXPRESSION IN MULTIPLE-SCLEROSIS LESIONS
Autore:
GEHRMANN J; BANATI RB; CUZNER ML; KREUTZBERG GW; NEWCOMBE J;
Indirizzi:
UNIV ZURICH HOSP,INST CLIN PATHOL,DEPT PATHOL,SCHMELZBERGSTR 12 CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,INST NEUROPATHOL CH-8091 ZURICH SWITZERLAND MAX PLANCK INST PSYCHIAT W-8033 MARTINSRIED GERMANY NEUROL INST,MS LAB LONDON ENGLAND
Titolo Testata:
Glia
fascicolo: 2, volume: 15, anno: 1995,
pagine: 141 - 151
SICI:
0894-1491(1995)15:2<141:APP(EI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; WHITE MATTER; BRAIN; OLIGODENDROCYTES; LOCALIZATION; MICROGLIA; CELLS; ISCHEMIA; INJURY;
Keywords:
AMYLOID PRECURSOR PROTEIN; ACUTE PHASE PROTEINS; DEMYELINATION; MICROGLIA; ASTROCYTES; MULTIPLE SCLEROSIS; AXONAL DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Gehrmann et al., "AMYLOID PRECURSOR PROTEIN (APP) EXPRESSION IN MULTIPLE-SCLEROSIS LESIONS", Glia, 15(2), 1995, pp. 141-151

Abstract

The amyloid precursor protein (APP) is rapidly induced in reactive glial cells in response to several pathological stimuli including inflammation. In the present study, observations previously made in animal models of autoimmune central nervous system inflammation have been extended to the analysis of multiple sclerosis (MS) lesions. A total of thirty fresh-frozen tissue blocks from six histopathologically normal control and six MS eases have been examined immunocytochemically with monoclonal antibodies directed against either C- or N-terminal epitopes of APP. Histopathological evaluation of disease progression was based on hematoxylin-eosin and oil red O staining and immunocytochemistry for T cells, macrophages/microglia, astrocytes, and oligodendrocytes. Incontrol cases, APP immunoreactivity was generally low and confined toblood vessel walls, oligodendrocytes in white, and neurons in grey matter. In actively demyelinating plaques, however, levels of APP immunoreactivity were high, localised on T lymphocytes, foamy macrophages, activated microglia, and reactive astrocytes including astrocytic processes. In more chronic lesions, levels of APP immunoreactivity were generally lower than in acute lesions, mainly found on reactive astrocytes, their processes and a few macrophages/microglia depending on the stage of plaque development. In addition, a few 14E-positive oligodendrocytes and, moreover, numerous axons exhibited APP immunoreactivity, which was particularly pronounced with anti-C-terminal antibodies. Theseresults demonstrate that APP is induced on reactive glial cells but also on T lymphocytes during demyelination. The extent of APP expression appears to be correlated to histopathological lesion development andthus suggests that APP detection serves as a sensitive marker for disease progression in MS. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:57:00