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Titolo:
ALPHA(2)-ADRENOCEPTORS AND THE REGULATION OF GLUCOSE, INSULIN AND AMYLIN LEVELS IN DIABETIC RATS
Autore:
GUILLOT E; COSTE A; ANGEL I;
Indirizzi:
DEPT INTERNAL MED,SYNTHELABO RECH,10 RUE CARRIERES,BP 248 F-92504 RUEIL MALMAISON FRANCE DEPT INTERNAL MED,SYNTHELABO RECH F-92504 RUEIL MALMAISON FRANCE
Titolo Testata:
Life sciences
fascicolo: 23, volume: 57, anno: 1995,
pagine: 2081 - 2090
SICI:
0024-3205(1995)57:23<2081:AATROG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET AMYLOID POLYPEPTIDE; ALPHA-2 ADRENOCEPTOR AGONISTS; GENE-RELATED PEPTIDE; PERIPHERAL ALPHA-2-ADRENOCEPTORS; INDUCED HYPERGLYCEMIA; PERFUSED PANCREAS; SECRETION; RELEASE; RESERPINE; CATECHOLAMINES;
Keywords:
DIABETES MELLITUS; ALPHA2-ADRENOCEPTORS; STREPTOZOTOCIN; GLUCOSE; INSULIN; AMYLIN; UK 14304; DERIGLIDOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Guillot et al., "ALPHA(2)-ADRENOCEPTORS AND THE REGULATION OF GLUCOSE, INSULIN AND AMYLIN LEVELS IN DIABETIC RATS", Life sciences, 57(23), 1995, pp. 2081-2090

Abstract

The effects of the selective alpha(2)-adrenoceptor agonist UK 14.304 on glucose, insulin and amylin levels were examined in neonatal streptozotocin-induced diabetic rats. UK 14.304 (0.03 to 0.3 mg/kg i.p.) induced a dose-dependent reduction of both insulin and amylin levels in normal rats while UK 14.304 at 0.03 mg/kg had already a maximal effect in diabetic rats. Amylin/insulin molar ratios rose after UK 14.304 administration in diabetic rats but remainded constant in normal rats. The alpha(2)-adrenoceptor antagonist deriglidole (3 mg/kg i.p.) slightlyincreased insulin and amylin levels in the two groups of rats but glucose levels were more markedly decreased in diabetic rats. Deriglidolecompletely antagonized UK 14.304 (0.1 mg/kg i.p.)-induced changes thereby normalizing amylin/insulin molar ratios in diabetic rats. These results suggest that insulin and amylin are both under inhibitory control via alpha(2)-adrenoceptor though the responses may be differentially regulated. It is further suggested that diabetes in the neonatal streptozotocin-induced rat model is associated with a hypersensitivity ofthe pancreas to alpha(2)-adrenoceptor stimulation.

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Documento generato il 29/11/20 alle ore 16:09:45