Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HETEROGENOUS ENDOTHELIN RECEPTORS MEDIATE RELAXATION AND CONTRACTION IN THE GUINEA-PIG ILEUM
Autore:
MIASIRO N; KARAKI H; PAIVA ACM;
Indirizzi:
ESCOLA PAULISTA MED,DEPT BIOFIS,CP 20388,RUA BOTUCATU 862 BR-04023062SAO PAULO BRAZIL UNIV TOKYO,FAC AGR,DEPT VET PHARMACOL TOKYO 113 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 285, anno: 1995,
pagine: 247 - 254
SICI:
0014-2999(1995)285:3<247:HERMRA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CONTRACTION; VASOCONSTRICTOR PEPTIDE; NA+ IONS; CLONING; FAMILY; SARAFOTOXIN; IRL-1620; AGONIST; CELLS; ISOPEPTIDES;
Keywords:
ENDOTHELIN; IRL1620; ENDOTHELIN RECEPTOR SUBTYPE; PD145065; BQ-123; TACHYPHYLAXIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
N. Miasiro et al., "HETEROGENOUS ENDOTHELIN RECEPTORS MEDIATE RELAXATION AND CONTRACTION IN THE GUINEA-PIG ILEUM", European journal of pharmacology, 285(3), 1995, pp. 247-254

Abstract

IRL1620, a specific endothelin ET(B) receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range studied. Repeated administration of IRL1620 induced tachyphylaxis only of the contractile component, whereas endothelin-l desensitized both components. BQ-123 (cyclo[D-Trp-D-Asp-Pro-D-Val-Leu]), a specific endothelin ET(A) receptor antagonist, did not inhibit the relaxation induced by either agonist, although it did inhibit the contractioninduced by endothelin-1, but not by IRL1620. PD145065 (Ac-(D-Bhg-Leu-Asp-Ile-Ile-Trp) (D-Bhg = -dibenzyl[a,d]cycloheptene-10,11-dihydroglycine)), a combined endothelin ET(A)/endothelin ET(B) receptor antagonist, inhibited the contractile effects of both endothelin-1 and IRL1620 and also inhibited the relaxation induced by IRL1620. Apamin, a Ca2+-activated K+ channel blocker, inhibited only the endothelin-1-induced relaxation. Our studies suggest that two endothelin ET(B) receptor subtypes mediate relaxation in the guinea-pig ileum: one is less sensitiveto PD145065 but apamin-inhibitable, and the other is more sensitive to PD145065 but not apamin-inhibitabie. Our results also suggest that both endothelin ET(A) and endothelin ET(B) receptor subtypes mediate contraction in the ileum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:47:42