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Titolo:
INSULIN-TREATMENT AFFECTS BRAIN PROTEIN-SYNTHESIS RATE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Autore:
HAYASE K; YOKOGOSHI H;
Indirizzi:
AICHI UNIV EDUC,DEPT HOME ECON KARIYA AICHI 448 JAPAN UNIV SHIZUOKA,SCH FOOD & NUTR SCI,NUTR BIOCHEM LAB YADA SHIZUOKA 422 JAPAN
Titolo Testata:
The Journal of nutrition
fascicolo: 11, volume: 125, anno: 1995,
pagine: 2768 - 2772
SICI:
0022-3166(1995)125:11<2768:IABPRI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC POLYRIBOSOME PROFILES; DIETARY-PROTEIN; MUSCLE GROWTH; TURNOVER; TISSUES; QUALITY; DISAGGREGATION; CORTICOSTERONE; RECEPTORS; QUANTITY;
Keywords:
INSULIN; DIABETES; PROTEIN SYNTHESIS; BRAIN; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Hayase e H. Yokogoshi, "INSULIN-TREATMENT AFFECTS BRAIN PROTEIN-SYNTHESIS RATE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS", The Journal of nutrition, 125(11), 1995, pp. 2768-2772

Abstract

The purpose of this study was to determine whether insulin treatment affected the rate of brain protein synthesis in diabetic rats. Experiments were conducted on three groups of rats given streptozotocin without insulin treatment (diabetes), treated with streptozotocin + insulin(diabetes + insulin) or treated with neither streptozotocin nor insulin (control). The fractional rates of protein synthesis in brain, liver and kidney of diabetic rats treated with insulin were significantly greater than in diabetic rats without insulin treatment, In brain, liver and kidney, the RNA activity [g protein synthesized/(g RNA . d)] was significantly correlated with the fractional rate of protein synthesis, The RNA concentration (mg RNA/g protein) was not related to the fractional rate of protein synthesis in any organ. The results suggest that insulin treatment of diabetic rats is likely to increase the rate of protein synthesis in the brain, and that RNA activity is related tothe fractional rate of brain protein synthesis.

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Documento generato il 01/12/20 alle ore 10:44:41