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Titolo:
TECHNETIUM-99M-SESTAMIBI IMAGING WITH NITRATE INFUSION TO DETECT VIABLE HIBERNATING MYOCARDIUM AND PREDICT POSTREVASCULARIZATION RECOVERY
Autore:
BISI G; SCIAGRA R; SANTORO GM; ROSSI V; FAZZINI PF;
Indirizzi:
UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,NUCL MED UNIT,VIALE MORGAGNI 85 I-50134 FLORENCE ITALY UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,NUCL MED UNIT I-50134 FLORENCE ITALY CAREGGI HOSP,DIV CARDIOL FLORENCE ITALY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 11, volume: 36, anno: 1995,
pagine: 1994 - 2000
SICI:
0161-5505(1995)36:11<1994:TIWNIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; EMISSION COMPUTED-TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; METHOXYISOBUTYL ISONITRILE; BLOOD-FLOW; TECHNETIUM-99M-METHOXYISOBUTYL ISONITRILE; TL-201 TOMOGRAPHY; NITROGLYCERIN; SCINTIGRAPHY; REINJECTION;
Keywords:
FIRST-PASS RADIONUCLIDE ANGIOCARDIOGRAPHY; HIBERNATING MYOCARDIUM; NITRATES; TECHNETIUM-99M-SESTAMIBI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
G. Bisi et al., "TECHNETIUM-99M-SESTAMIBI IMAGING WITH NITRATE INFUSION TO DETECT VIABLE HIBERNATING MYOCARDIUM AND PREDICT POSTREVASCULARIZATION RECOVERY", The Journal of nuclear medicine, 36(11), 1995, pp. 1994-2000

Abstract

We tested the relationship of nitrate-induced changes in (TC)-T-99m-sestamibi perfusion tomography and first-pass radionuclide angiocardiography (FPRNA) with postrevascularization functional recovery of asynergic territories. Methods: Twenty-eight patients, all with prior infarction and left ventricular dysfunction, underwent two Tc-99m-sestamibi rest studies: one under baseline conditions and the other with nitrateinfusion. The baseline study was repeated after revascularization. Changes in global and regional perfusion and ventricular function were evaluated by perfusion tomography and FPRNA. Hibernating myocardium wasidentified by functional recovery in postrevascularization FPRNA. Results: Eleven patients and 31 segments in 19 coronary territories had functional recovery. Nitrate-induced FPRNA changes showed poor agreement with postrevascularization modifications: kappa = 0.24, ns, for the global and kappa = 0.32, p < 0.01 for regional function. The agreementbetween nitrate-induced and postrevascularization perfusion changes was good both considering the patients (k = 0.57, p < 0.01) and the abnormal coronary territories (k = 0.63, p < 0.0005). The agreement of nitrate-induced perfusion changes with postrevascularization functional outcome was excellent on a patient (k = 1, p < 0.0005), and coronary territory basis (k = 0.82, p < 0.0005). Conversely, the agreement between nitrate and postrevascularization FPRNA was poor: k = 0.18, ns. Conclusion: These data suggest that the nitrate-induced changes in Tc-99m-sestamibi perfusion imaging are useful to detect hibernating myocardium which recovers its function after revascularization.

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Documento generato il 30/03/20 alle ore 10:11:45