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Titolo:
ALPHA(2)-ADRENOCEPTORS IN THE TREATMENT OF DEMENTIA - AN ATTENTIONAL MECHANISM
Autore:
COULL JT;
Indirizzi:
INST NEUROL,WELLCOME DEPT COGNIT NEUROL,12 QUEEN SQ LONDON WC1N 3BG ENGLAND
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
, volume: 10, anno: 1996, supplemento:, 3
pagine: 43 - 48
SICI:
0269-8811(1996)10:<43:AITTOD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE TYPE; PARKINSONS-DISEASE; NORADRENERGIC FUNCTION; SCHIZOPHRENIC-PATIENTS; SUBCORTICAL DEMENTIA; KORSAKOFFS PSYCHOSIS; SUSTAINED ATTENTION; ALZHEIMERS-DISEASE; COGNITIVE DEFICITS; IMPROVES MEMORY;
Keywords:
FRONTAL; ATTENTION; DEMENTIA; COGNITIVE ENHANCER; CLONIDINE; YOHIMBINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Coull, "ALPHA(2)-ADRENOCEPTORS IN THE TREATMENT OF DEMENTIA - AN ATTENTIONAL MECHANISM", J PSYCHOPH, 10, 1996, pp. 43-48

Abstract

Drugs acting on the noradrenergic alpha(2)-adrenoceptors have been postulated to improve cognitive function in dementias such as Parkinson's disease, schizophrenia and Korsakoff's disease. Furthermore, research from our own group has suggested a novel therapeutic use for alpha(2)-antagonists in treatment of the cognitive symptomatology of patientssuffering from dementia of frontal type (DFT). Relatively selective idazoxan-induced changes in performance were found in these patients ontests previously found to be sensitive to frontal lobe dysfunction, suggestive of a direct effect of alpha(2)-agents on frontal lobe function. However, the possibility is also discussed that this effect may actually be due to an action on underlying attentional mechanisms, whichmay themselves be dependent on pre-frontal functioning. These resultsnot only provide a rationale for the pharmacological treatment of DFT, but also contribute to the theoretical understanding of the psychopharmacological effects of alpha(2)-agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:31:49