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Titolo:
BIOLOGICAL PHENOTYPES OF HIV-1 SUBTYPE-A AND SUBTYPE-B STRAINS OF DIVERSE ORIGINS
Autore:
NKENGASONG JN; PEETERS M; ZHONG P; WILLEMS B; JANSSENS W; HEYNDRICKX L; FRANSEN K; NDUMBE PM; GERSHYDAMET GM; NYS P; KESTENS L; PIOT P; VANDERGROEN G;
Indirizzi:
INST TROP MED,CTR AIDS & STD,DEPT INFECT & IMMUN,DIV MICROBIOL,155 NATL STR B-2000 ANTWERP BELGIUM UNIV YAOUNDE 1,FAC MED & BIOMED SCI,CTR STUDY & CONTROL COMMUNICABLE DIS YAOUNDE CAMEROON INST PASTEUR ABIDJAN COTE IVOIRE INST BIOL PROD SHANGHAI PEOPLES R CHINA ORSTOM,RETROVIRUS LAB F-34032 MONTPELLIER FRANCE
Titolo Testata:
Journal of medical virology
fascicolo: 3, volume: 47, anno: 1995,
pagine: 278 - 284
SICI:
0146-6615(1995)47:3<278:BPOHSA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; AMINO-ACID CHANGES; T-CELL-LINE; VIRAL PHENOTYPE; TYPE-1 HIV-1; AIDS; INFECTION; VARIANTS; TROPISM; GP120;
Keywords:
AFRICA; BELGIUM; HIV-1 HETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.N. Nkengasong et al., "BIOLOGICAL PHENOTYPES OF HIV-1 SUBTYPE-A AND SUBTYPE-B STRAINS OF DIVERSE ORIGINS", Journal of medical virology, 47(3), 1995, pp. 278-284

Abstract

The identification of specific biologic phenotypic traits that can becorrelated with different HIV-1 genetic subtypes was sought. The genetic subtypes were determined by either sequencing (Cameroonian strains, n = 18) or by the heteroduplex mobility assay (HMA) (Belgian strains, n = 21 and Ivorian strains, n = 25). Seventeen (81%) of the 21 Belgian isolates belonged to subtype B and 4 (17%) were subtype A strains. Subtype A variants were predominant in the two African countries studied; 11 (61%) of 18 strains from Cameroon and 23 (92%) of 25 strains from the Ivory Coast. Of the 64 isolates, 38 (58%) and 19 (29%) belongedto subtypes A and B, respectively. No significant difference was observed for biological phenotypes (slow/low and rapid/high) of both genetic subtypes. In symptomatic individuals, however, a significantly higher number of subtype B isolates were of rapid/high phenotype, com pared with subtype A (5 of 10; 50%) vs. 2 of 22; 9%), respectively; X(2) =6.7, P = 0.02). The findings suggest that overall HIV-1 isolates belonging to genetic subtype B are not distinguishable from subtype A variants on the basis of their biological phenotypes. Syncytium-induci ng variants were less prevalent regardless of the geographic origin of the isolates. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:04:46