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Titolo:
FOREBRAIN CONTRIBUTION TO THE INDUCTION OF A CELLULAR CORRELATE OF CONDITIONED TASTE-AVERSION IN THE NUCLEUS OF THE SOLITARY TRACT
Autore:
SCHAFE GE; SEELEY RJ; BERNSTEIN IL;
Indirizzi:
UNIV WASHINGTON,DEPT PSYCHOL,119 GUTHRIE HALL,BOX 351525 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PSYCHOL SEATTLE WA 98195
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 15, anno: 1995,
pagine: 6789 - 6796
SICI:
0270-6474(1995)15:10<6789:FCTTIO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DECEREBRATE RATS; AREA POSTREMA; LITHIUM-CHLORIDE; LESIONS; REACTIVITY; RESPONSES; NEURONS; VAGAL;
Keywords:
C-FOS; DECEREBRATE RATS; LEARNING; BRAIN-STEM; LITHIUM CHLORIDE; AVERSION CONDITIONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Schafe et al., "FOREBRAIN CONTRIBUTION TO THE INDUCTION OF A CELLULAR CORRELATE OF CONDITIONED TASTE-AVERSION IN THE NUCLEUS OF THE SOLITARY TRACT", The Journal of neuroscience, 15(10), 1995, pp. 6789-6796

Abstract

A conditioned taste aversion (CTA) is a form of classical conditioning in which animals avoid a taste (conditioned stimulus; CS) which has been previously paired with a treatment (unconditioned stimulus; US) that produces transient illness. Recently, a reliable cellular correlate of the behavioral expression of a CTA was identified using c-Fos immunostaining as a marker of neuronal activation. Exposure to a saccharin solution (CS) which had previously been paired with lithium chloride(LiCl; US) induced significant c-fos-like immunoreactivity (c-FLI) inthe intermediate zone of the nucleus of the solitary tract (NTS), a response that was quite similar to that displayed following administration of LiCl alone. The present studies employed a variant of the chronic decerebrate rat preparation to explore whether circuitry intrinsic to the brainstem is sufficient for the induction of c-FLI in NTS both as an unconditioned response to the LiCl and as a conditioned responseto the saccharin. Using chronic hemidecerebrate rats, which have a unilateral brain transection at the level of the superior colliculus, wefound that the unconditioned c-FLI to LiCl was unaltered by the transection, while the conditioned expression of c-FLI to the CS taste was evident only on the side of the NTS which retained neural connections with the forebrain. These findings strongly implicate forebrain input in this cellular correlate of CTA learning and also indicate that the pathways mediating the response to the US (LiCl) and the CS (saccharin) differ.

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Documento generato il 24/09/20 alle ore 22:43:13