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Titolo:
LOCALIZATION OF NOVEL CORTICOTROPIN-RELEASING FACTOR-RECEPTOR (CRF(2)) MESSENGER-RNA EXPRESSION TO SPECIFIC SUBCORTICAL NUCLEI IN RAT-BRAIN- COMPARISON WITH CRF(1) RECEPTOR MESSENGER-RNA EXPRESSION
Autore:
CHALMERS DT; LOVENBERG TW; DESOUZA EB;
Indirizzi:
NEURCRINE BIOSCI INC,3050 SCI PK RD SAN DIEGO CA 92121
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 15, anno: 1995,
pagine: 6340 - 6350
SICI:
0270-6474(1995)15:10<6340:LONCF(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MAJOR DEPRESSION; BETA-ENDORPHIN; NEURONS; FIBERS; CLONING; COMPLEX; CELLS;
Keywords:
CORTICOTROPIN-RELEASING FACTOR (CRF); STRESS; CRF RECEPTORS; MESSENGER-RNA EXPRESSION; BRAIN; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Chalmers et al., "LOCALIZATION OF NOVEL CORTICOTROPIN-RELEASING FACTOR-RECEPTOR (CRF(2)) MESSENGER-RNA EXPRESSION TO SPECIFIC SUBCORTICAL NUCLEI IN RAT-BRAIN- COMPARISON WITH CRF(1) RECEPTOR MESSENGER-RNA EXPRESSION", The Journal of neuroscience, 15(10), 1995, pp. 6340-6350

Abstract

Corticotropin-releasing factor (CRF) is the primary factor involved in controlling the release of ACTH from the anterior pituitary and alsoacts as a neurotransmitter in a variety of brain systems. The actionsof CRF are mediated by G-protein coupled membrane bound receptors anda high affinity CRF receptor, CRF(1), has been previously cloned and functionally characterized. We have recently isolated a cDNA encoding a second member of the CRF(1) receptor family, designated CRF(2), which displays approximately 70% homology at the nucleotide level to the CRF(1) receptor and exhibits a distinctive pharmacological profile. Thepresent study utilized in situ hybridization histochemistry to localize the distribution of CRF(2) receptor mRNA in rat brain and pituitarygland and compared this with the distribution of CRF(1) receptor expression. While CRF(1) receptor expression was very high in neocortical,cerebellar, and sensory relay structures, CRF(2) receptor expression was generally confined to subcortical structures. The highest levels of CRF(2) receptor mRNA in brain were evident within the lateral septalnucleus, the ventromedial hypothalamic nucleus and the choroid plexus. Moderate levels of CRF(2) receptor expression were evident in the olfactory bulb, amygdaloid nuclei, the paraventricular and suraoptic nuclei of the hypothalamus, the inferior colliculus and 5-HT-associated raphe nuclei of the midbrain. CRF(2)-expressing cells were also evidentin the bed nucleus of the stria terminalis, the hippocampal formationand anterior and lateral hypothalmic areas. In addition, CRF(2) receptor mRNA was also found in cerebral arterioles throughout the brain. Within the pituitary gland, CRF(2) receptor mRNA was detectable only atvery low levels in scattered cells while CRF(1) receptor mRNA was readily detectable in anterior and intermediate lobes. This heterogeneousdistribution of CRF(1) and CRF(2) receptor mRNA suggests distinctive functional roles for each receptor in CRF-related systems. The CRF(1) receptor may be regarded as the primary neuroendocrine pituitary CRF receptor and important in cortical, cerebellar and sensory roles of CRF. The anatomical distribution of CRF(2) receptor mRNA indicates a rolefor this novel receptor in hypothalamic neuroendocrine, autonomic andgeneral behavioral actions of central CRF.

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Documento generato il 28/11/20 alle ore 04:18:09