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Titolo:
BAROSENSITIVE NEURONS IN THE ROSTRAL VENTROLATERAL MEDULLA OF THE RATIN-VIVO - MORPHOLOGICAL PROPERTIES AND RELATIONSHIP TO C1 ADRENERGIC-NEURONS
Autore:
LIPSKI J; KANJHAN R; KRUSZEWSKA B; SMITH M;
Indirizzi:
UNIV AUCKLAND,SCH MED,DEPT PHYSIOL,PRIVATE BAG 92-019 AUCKLAND NEW ZEALAND
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 69, anno: 1995,
pagine: 601 - 618
SICI:
0306-4522(1995)69:2<601:BNITRV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYLETHANOLAMINE N-METHYLTRANSFERASE; NUCLEUS PARAGIGANTOCELLULARIS LATERALIS; SYMPATHETIC PREGANGLIONIC NEURONS; SPINAL-CORD; CARDIOVASCULAR NEURONS; BARORECEPTOR REFLEX; BRAIN-STEM; INTERMEDIOLATERAL NUCLEUS; CATECHOLAMINERGIC NEURONS; BULBOSPINAL NEURONS;
Keywords:
PRESYMPATHETIC (SYMPATHOEXCITATORY) NEURONS; INTRACELLULAR RECORDING AND LABELING; TYROSINE HYDROXYLASE; CENTRAL CARDIOVASCULAR CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
J. Lipski et al., "BAROSENSITIVE NEURONS IN THE ROSTRAL VENTROLATERAL MEDULLA OF THE RATIN-VIVO - MORPHOLOGICAL PROPERTIES AND RELATIONSHIP TO C1 ADRENERGIC-NEURONS", Neuroscience, 69(2), 1995, pp. 601-618

Abstract

The aim of this study, conducted in anaesthetized rats, was to examine the morphology of barosensitive neurons in the rostral ventrolateralmedulla and their immunoreactivity for a catecholamine synthesizing enzyme, tyrosine hydroxylase. Thirty neurons displaying inhibitory postsynyptic potentials following stimulation of the aortic depressor nerve were intracellularly labelled with Lucifer Yellow or Neurobiotin. Some of these neurons could be excited antidromically from the second thoracic segment of the spinal cord, with conduction velocities of spinal axons ranging from 1.9 to 7.2 m/s. The filled somas were found immediately caudal to the facial nucleus and ventral or ventromedial to compact formation of the nucleus ambiguus. Some dendrites reached the ventral medullary surface. Axons usually projected dorsomedially and thenmade a sharp rostral and/or caudal turn. The caudally projecting axoncould, in some cases, be followed to the first cervical segment of the spinal cord. Seven cells issued fine axon collaterals on the ipsilateral side. These were identified mainly in two areas: in the rostral ventrolateral medulla (or immediately dorsomedial to that region), and within the dorsal vagal complex. Seven of 27 examined cells (26%) weretyrosine hydroxylase-immunoreactive and were classified as C1 adrenergic neurons. No clear relationship was found between the presence or absence of adrenergic phenotype and the morphology of filled cells. However, the amplitude of aortic nerve-evoked inhibitory postsynaptic potentials was significantly larger in tyrosine hydroxylase-positive neurons. Possible reasons for the low percentage of barosensitive cells with tyrosine hydroxylase immunoreactivity found in this study, in comparison with previously published estimates, are discussed. This is the first study describing the morphology of neurons in this part of the medulla identified as barosensitive in vivo, and directly demonstratingadrenergic phenotype in a subset of these neurons.

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Documento generato il 02/04/20 alle ore 22:12:13