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Titolo:
POTENTIATION OF N-METHYL-D-ASPARTATE-RECEPTOR-MEDIATED CURRENTS DETECTED USING THE EXCISED PATCH TECHNIQUE IN THE HIPPOCAMPAL DENTATE GYRUS
Autore:
OCONNOR JJ; WU J; ROWAN MJ; ANWYL R;
Indirizzi:
TRINITY COLL DUBLIN,DEPT PHARMACOL & THERAPEUT DUBLIN 2 IRELAND TRINITY COLL DUBLIN,DEPT PHARMACOL & THERAPEUT DUBLIN 2 IRELAND TRINITY COLL DUBLIN,DEPT PHYSIOL DUBLIN 2 IRELAND
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 69, anno: 1995,
pagine: 363 - 369
SICI:
0306-4522(1995)69:2<363:PONCD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; EVOKED RELEASE; GROWTH CONES; ACETYLCHOLINE; TRANSMITTER; NEURONS;
Keywords:
LONG-TERM POTENTIATION; GLUTAMATE RELEASE; NMDA SINGLE CHANNEL CURRENTS; EXCITATORY POSTSYNAPTIC CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Oconnor et al., "POTENTIATION OF N-METHYL-D-ASPARTATE-RECEPTOR-MEDIATED CURRENTS DETECTED USING THE EXCISED PATCH TECHNIQUE IN THE HIPPOCAMPAL DENTATE GYRUS", Neuroscience, 69(2), 1995, pp. 363-369

Abstract

The excised patch mode of the patch-clamp technique has been used to record isolated patch N-methyl-D-aspartate-receptor-mediated currents (patch NMDA-receptor-currents) evoked by electrical stimulation in thedentate gyrus of the hippocampal slice. The patch NMDA-receptor-currents were recorded by placing a patch of membrane isolated from the cell body in the inner molecular layer of the dentate gyrus and applying stimulation to the proximal commissural/associational pathway. The patch NMDA-receptor-currents, recorded at +40 mV in the presence of AMPA-receptor and GABA(A)-receptor antagonists, consisted of two to six summated unitary openings of NMDA-receptor channels, lasting several hundred milliseconds. Tetanic pathway stimulation evoked a rapid increase in the amplitude of the patch NMDA-receptor-currents which lasted for a period of at least 20 min following the tetanus. The study suggests that the potentiation of the patch NMDA-receptor-currents is due to either an increase in transmitter release, or alternatively, to the release of an extracellular messenger which directly enhances NMDA-receptor responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:30:09