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Titolo:
REPEATED INESCAPABLE STRESS PRODUCES A NEUROLEPTIC-LIKE EFFECT ON THECONDITIONED AVOIDANCE-RESPONSE
Autore:
FRIEDHOFF AJ; CARR KD; UYSAL S; SCHWEITZER J;
Indirizzi:
NYU,MED CTR,SCH MED,DEPT PSYCHIAT,MILHAUSER LABS,ROOM HN-323,550 1ST AVE NEW YORK NY 10016
Titolo Testata:
Neuropsychopharmacology
fascicolo: 2, volume: 13, anno: 1995,
pagine: 129 - 138
SICI:
0893-133X(1995)13:2<129:RISPAN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HALOPERIDOL TREATMENT; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; DOPAMINE SYSTEMS; SCHIZOPHRENIA; RATS; 6-HYDROXYDOPAMINE; INJECTIONS; BEHAVIOR; NEURONS;
Keywords:
CONDITIONED AVOIDANCE RESPONSE; DOPAMINE; STRESS; RESTITUTIVE SYSTEMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Friedhoff et al., "REPEATED INESCAPABLE STRESS PRODUCES A NEUROLEPTIC-LIKE EFFECT ON THECONDITIONED AVOIDANCE-RESPONSE", Neuropsychopharmacology, 13(2), 1995, pp. 129-138

Abstract

This study tests the hypothesis that the dopaminergic system mediatesa restitutive response by decreasing its own activity in the face of events like persistent inescapable stress that threaten to interrupt organized mental activity. It is well established that neuroleptic drugs inhibit the conditioned avoidance response (CAR), but not the escaperesponse, probably via a reduction in subcortical dopaminergic activity. We trained rats to perform the CAR and then subjected them to acute and chronic stress to determine whether this would result in inhibition of the CAR. Rats subjected to tu,ice daily tailshock stress for 8 days showed inhibition of the CAR and a reduction in dopamine (DA) utilization in the nucleus accumbens. These findings are compatible with the hypothesis that an endogenous DA-dependent mechanism exists that mimics neuroleptic effects in the face of repeated stress. In humans this response may serve as a protection against psychotic decompensationfrom chronic endogenous or exogenous insult.

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Documento generato il 25/01/20 alle ore 18:47:27