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Titolo:
INDUCTION OF CIRCULATING INTERLEUKIN-10 BY INTERLEUKIN-1 AND INTERLEUKIN-2, BUT NOT INTERLEUKIN-6 IMMUNOTHERAPY
Autore:
TILG H; ATKINS MB; DINARELLO CA; MIER JW;
Indirizzi:
UNIV INNSBRUCK HOSP,DEPT MED,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA TUFTS UNIV,SCH MED BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV GEOG MED & INFECT DIS BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL BOSTON MA 02111
Titolo Testata:
Cytokine
fascicolo: 7, volume: 7, anno: 1995,
pagine: 734 - 739
SICI:
1043-4666(1995)7:7<734:IOCIBI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LIPOPOLYSACCHARIDE; ENDOTOXEMIA; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
H. Tilg et al., "INDUCTION OF CIRCULATING INTERLEUKIN-10 BY INTERLEUKIN-1 AND INTERLEUKIN-2, BUT NOT INTERLEUKIN-6 IMMUNOTHERAPY", Cytokine, 7(7), 1995, pp. 734-739

Abstract

The objective of this study was to investigate the in vivo productionof interleukin 10 (IL-10) in cancer patients undergoing immunotherapywith IL-1 alpha, IL-2 or IL-6 and to study the effect of the same cytokines on the in vitro synthesis of IL-10 by human monocytes and macrophages, In the IL-1 alpha clinical trial, patients received 0.03 g/kg of IL-1 alpha as a 30 minute infusion daily for 5 consecutive days. Inthese patients, plasma IL-10 levels rose rapidly and peaked within 1 h (121 +/- 16 pg/mL; n = 4) after the first IL-1 alpha infusion. Thereafter, the levels rapidly declined to baseline within 8 h. The peak plasma IL-10 levels measured on days 3 and 5 of therapy were somewhat less pronounced than those on day 1, IL-2 immunotherapy was also associated with the induction of circulating IL-10. These patients were treated with high-dose (6 x 10(5) IU/kg) IL-2 every 8 h for 5 consecutive days, IL-10 was detectable in these patients within 2-4 h after the first IL-2 infusion (10(5) +/- 12 pg/mL), In contrast to the transient bursts of IL-10 detected in patients treated with IL-1 alpha, IL-10 levels progressively increased throughout the treatment course in the IL-2-treated patients reaching peak levels on day 5 (240 +/- 22 pg/mL; n =10), IL-6 immunotherapy with a 5-day continuous infusion was not associated with detectable levels of circulating IL-10. Peripheral blood mononuclear cells and in vitro-derived macrophages synthesized similar amounts of IL-10 after stimulation with IL-1 alpha or IL-2, but were unresponsive to IL-6. These results suggest that the proinflammatory cytokines IL-1 alpha and IL-2 induce the anti-inflammatory cytokine IL-10 in vitro and in vivo, whereas IL-6 is not able to stimulate IL-10 synthesis. (C) 1995 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:23:55