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Titolo:
IN-VITRO AND IN-VIVO SENSITIVITY OF A NON-MOUSE-ADAPTED INFLUENZA-A (BEIJING) VIRUS-INFECTION TO AMANTADINE AND RIBAVIRIN
Autore:
SIDWELL RW; BAILEY KW; WONG MH; HUFFMAN JH;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES LOGAN UT 84322
Titolo Testata:
Chemotherapy
fascicolo: 6, volume: 41, anno: 1995,
pagine: 455 - 461
SICI:
0009-3157(1995)41:6<455:IAISOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAZOLE; -BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE; INHIBITION;
Keywords:
INFLUENZA VIRUS; AMANTADINE; RIBAVIRIN; ANTIVIRAL AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Sidwell et al., "IN-VITRO AND IN-VIVO SENSITIVITY OF A NON-MOUSE-ADAPTED INFLUENZA-A (BEIJING) VIRUS-INFECTION TO AMANTADINE AND RIBAVIRIN", Chemotherapy, 41(6), 1995, pp. 455-461

Abstract

A clinically isolated non-mouse-adapted influenza A/Beijing/32/92 virus was assayed for sensitivity to amantadine and ribavirin in vitro and in mice. When multiple concentrations of each drug were assayed for ability to inhibit the virus-induced cytopathic effect in MDCK cells, the 50% effective (virus-inhibitory) concentration was 0.12 mu g/ml for amantadine and 1.9 mu g/ml for ribavirin. The 50% cytotoxic concentrations were 25 and 100 mu g/ml, respectively. It is known that intranasal challenge of mice with high concentrations of non-mouse-adapted influenza virus will induce a toxic pneumonitis in the absence of significant viral replication in the lung. Treatment of such virus-infected mice with similar to 1,250, similar to 625 and similar to 313 mg/kg/day of amantadine in the drinking water resulted in significant inhibition of lung scores and weights and a lessened decline in arterial oxygen saturation (SaO(2)) in the mice, but virus was in low titer or not recoverable from drug- or placebo-treated animals. Intraperitoneal treatment with 75, 37.5 and 18.8 mg/kg/day of ribavirin given twice dally for 5 days was effective only in preventing SaO(2) decline, which contrasts with strong inhibition of infections induced by mouse-adapted viruses seen in other studies. These in vivo data indicate that when non-mouse-adapted influenza virus infections are used to evaluate potential antiviral drugs, false-negative results may be obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:26:21