Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVIDENCE FOR ARGININE-VASOPRESSIN AS THE PRIMARY ACTIVATOR OF THE HPAAXIS DURING ADJUVANT-INDUCED ARTHRITIS
Autore:
CHOWDREY HS; LARSEN PJ; HARBUZ MS; JESSOP DS; AGUILERA G; ECKLAND DJA; LIGHTMAN SL;
Indirizzi:
UNIV BRISTOL,BRISTOL ROYAL INFIRM,DEPT MED,MARLBOROUGH ST BRISTOL BS28HW AVON ENGLAND UNIV GREENWICH,SCH CHEM & LIFE SCI LONDON SE18 6PF ENGLAND UNIV COPENHAGEN,INST MED ANAT,DEPT B COPENHAGEN DENMARK NICHHD,ENDOCRINE PHYSIOL SECT BETHESDA MD 20892 NORTHWICK PK HOSP & CLIN RES CTR,GLAXO GRP RES,CLIN PHARMACOL UNIT HARROW HA1 3UJ MIDDX ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 5, volume: 116, anno: 1995,
pagine: 2417 - 2424
SICI:
0007-1188(1995)116:5<2417:EFAATP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; STRESS ENHANCES VASOPRESSIN; RAT ANTERIOR-PITUITARY; FACTOR MESSENGER-RNA; PARVOCELLULAR NEUROSECRETORY NEURONS; HYPOPHYSEAL PORTAL BLOOD; FACTOR CRF RECEPTORS; MEDIAN-EMINENCE; ADRENOCORTICOTROPIN SECRETION;
Keywords:
ARGININE VASOPRESSIN (AVP); CHRONIC STRESS; HPA-AXIS; ADJUVANT ARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Chowdrey et al., "EVIDENCE FOR ARGININE-VASOPRESSIN AS THE PRIMARY ACTIVATOR OF THE HPAAXIS DURING ADJUVANT-INDUCED ARTHRITIS", British Journal of Pharmacology, 116(5), 1995, pp. 2417-2424

Abstract

1 Adjuvant-induced arthritis (AA) is an experimental inflammation of the joints that results in chronic activation of the hypothalamo-pituitary-adrenal (HPA) axis. 2 In this study the role of hypothalamic corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) in the regulation of the HPA axis in this condition both in Sprague-Dawley (SD), and Piebald-Viral-Glaxo (PVG) rats has been further characterized. 3 The increase in AVP peptide content of portal blood (as early as day ii), just prior to the onset of arthritis is confirmed and furtherincreases, peaking at day 16 are shown, coincident with the progression of inflammation in the PVG rats. 4 The increase in AVP is associated with a significant increase in the expression of AVP but not CRF mRNAs in the medial parvocellular division of the hypothalamic paraventricular nucleus (PVN) of arthritic SD rats. 5 In the presence of maximalinflammation of SD rats there was a significant decrease in the maximum binding of [I-125]-Tyr-oCRF to anterior pituitary membranes, whereas AVP receptor concentration in anterior pituitary membranes from bothPVG and SD rats showed a significant increase with respect to controls. 6 The basal adrenocorticotrophin (ACTH) secretion in vitro was similar in both control and arthritic SD rats but that from arthritic PVG rat pituitaries was significantly greater than the respective controls(436 +/- 91 v 167 +/- 23 pg/tube). The ACTH response of pituitaries of arthritic PVG rats to CRF or the combination of CRF and AVP was significantly higher compared with the controls, although the ACTH response of arthritic SD rat pituitaries was unchanged. 7 The results are consistent with the view that activation of the parvocellular vasopressinsystem has an important role in the adaptation of the HPA axis to experimentally-induced chronic stress of arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:55:27