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Titolo:
CORTICOTROPIN-RELEASING FACTOR DECIDUALIZES HUMAN ENDOMETRIAL STROMALCELLS IN-VITRO - INTERACTION WITH PROGESTIN
Autore:
FERRARI A; PETRAGLIA F; GURPIDE E;
Indirizzi:
UNIV MODENA,SCH MED,DEPT OBSTET GYNECOL & PEDIAT SCI,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,SCH MED,DEPT OBSTET GYNECOL & PEDIAT SCI I-41100 MODENA ITALY MT SINAI SCH MED,DEPT OBSTET GYNECOL & REPROD SCI NEW YORK NY 10029
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 5-6, volume: 54, anno: 1995,
pagine: 251 - 255
SICI:
0960-0760(1995)54:5-6<251:CFDHES>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-FETAL MEMBRANES; HORMONE PRODUCTION; MONONUCLEAR-CELLS; PLACENTA; RECEPTORS; PREGNANCY; AFFINITY; ACTH; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Ferrari et al., "CORTICOTROPIN-RELEASING FACTOR DECIDUALIZES HUMAN ENDOMETRIAL STROMALCELLS IN-VITRO - INTERACTION WITH PROGESTIN", Journal of steroid biochemistry and molecular biology, 54(5-6), 1995, pp. 251-255

Abstract

Decidualization of endometrial cells is a hormone-dependent process of differentiation which occurs during the menstrual cycle and pregnancy. Recent in vitro studies have revealed that cAMP and its generators induce decidualization of stromal cells isolated from proliferative endometrium and that progestins enhance the effect of cAMP. Since corticotropin releasing factor (CRF) generates cAMP and prostaglandins in other organs, in the present study the effect of CRF, a hypothalamic factor also produced by decidua and fetal membranes, on in vitro decidualization of endometrial stromal cells was evaluated. The addition of CRF to a culture medium of stromal cells induced in vitro decidualization, as indicated by morphologic changes from elongated fibroblast-like cells into larger and round cells and by the release of prolactin in the medium. The effect of CRF on stromal cells and on prolactin releasewas significantly augmented by the coincubation in the presence of medroxyprogesterone acetate. This observation indicates CRF as a novel factor of decidualization and confirms that progestins act as enhancersof the expression of decidual products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:33:48