Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AGE-RELATED DIFFERENCES IN A CLOT LYSIS ASSAY AFTER ADDING DIFFERENT PLASMINOGEN ACTIVATORS IN A PLASMA MILIEU IN-VITRO
Autore:
RIES M; ZENKER M; KLINGE J; KEUPER H; HARMS D;
Indirizzi:
UNIV ERLANGEN NURNBERG,KINDER & JUGENDLICHE KLIN & POLIKLIN,LOSCHGESTR 15 D-91054 ERLANGEN GERMANY BEHRINGWERKE AG MARBURG GERMANY
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 3, volume: 17, anno: 1995,
pagine: 260 - 264
SICI:
1077-4114(1995)17:3<260:ADIACL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIDINE-RICH GLYCOPROTEIN; FULL-TERM NEWBORN; HUMAN COAGULATION SYSTEM; DYSFUNCTIONAL PLASMINOGEN; ALPHA-2-PLASMIN INHIBITOR; FIBRINOLYSIS; INFANTS; MECHANISM; UROKINASE; KINETICS;
Keywords:
FIBRINOLYSIS; THROMBOLYTIC THERAPY; NEWBORNS; PLASMINOGEN ACTIVATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Ries et al., "AGE-RELATED DIFFERENCES IN A CLOT LYSIS ASSAY AFTER ADDING DIFFERENT PLASMINOGEN ACTIVATORS IN A PLASMA MILIEU IN-VITRO", Journal of pediatric hematology/oncology, 17(3), 1995, pp. 260-264

Abstract

Purpose: The fibrinolytic system is involved in a wide variety of biological phenomena and differs physiologically in newborns compared to older children or adults. Because the newborn has hypoplasminogenemia and a possible existence of a dysfunctional plasminogen with normal adult levels of plasminogen activator inhibitor type 1 and alpha 2-antiplasmin and elevated levels of plasminogen activator inhibitor type 2, it could be expected that the response to standard concentrations and doses of plasminogen activators would be reduced. Patients and Methods: We have studied the kinetics of in vitro fibrinolysis after adding different concentrations of streptokinase(SK), urokinase(UK), and recombinant tissue plasminogen activator(rt-Ph) by use of a microtiter clotlysis assay. Results: Geometrical dilution rows showed characteristicdose response curves. After clot formation, a rapid lysis was seen with all plasminogen activators. The 50% lysis time correlated to the plasminogen activator dose and showed no differences among normal adults, children aged 1-6 years, and children aged 7-14 years. Newborns demonstrated a significantly prolonged 50% lysis time with all urokinase concentrations. The 50% lysis time with recombinant tissue plasminogen activator and streptokinase was significantly prolonged only at high concentrations, whereas we could not see any differences at lower concentrations. Conclusion: The experience with thrombolytic agents in newborns is limited, and no controlled investigations have been reported. Our results of the fibrinolytic potential in a plasma milieu in vitro after adding different plasminogen activators can be helpful to establish dosage guidelines for thrombolytic therapy in newborns and older children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:22:31