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Titolo:
ROLES OF PEPTIDES AND OTHER SUBSTANCES IN COTRANSMISSION FROM VASCULAR AUTONOMIC AND SENSORY NEURONS
Autore:
MORRIS JL; GIBBINS IL; KADOWITZ PJ; HERZOG H; KREULEN DL; TODA N; CLAING A;
Indirizzi:
FLINDERS UNIV S AUSTRALIA,SCH MED,DEPT ANAT & HISTOL,POB 2100 ADELAIDE SA 5001 AUSTRALIA TULANE UNIV,SCH MED,DEPT PHARMACOL NEW ORLEANS LA 70112 GARVAN INST MED RES DARLINGHURST NSW 2010 AUSTRALIA W VIRGINIA UNIV,ROBERT C BYRD HLTH SCI CTR,DEPT PHYSIOL MORGANTOWN WV26506 SHIGA UNIV MED SCI,DEPT PHARMACOL OTSU SHIGA 52021 JAPAN UNIV SHERBROOKE,SCH MED,DEPT PHARMACOL SHERBROOKE PQ J1H 5N4 CANADA
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 5, volume: 73, anno: 1995,
pagine: 521 - 532
SICI:
0008-4212(1995)73:5<521:ROPAOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; NEUROPEPTIDE-Y RECEPTOR; GENE-RELATED PEPTIDE; PIG UTERINE ARTERY; DORSAL-ROOT GANGLIA; CYCLASE-ACTIVATING POLYPEPTIDE; SYMPATHETIC-NERVE STIMULATION; FELINE CEREBRAL-ARTERIES; NON-NORADRENERGIC AXONS; GUINEA-PIG;
Keywords:
NEUROTRANSMISSION; BLOOD VESSELS; NEUROPEPTIDE Y (NPY); VASOACTIVE INTESTINAL PEPTIDE (VIP); CALCITONIN GENE RELATED PEPTIDE (CORP); PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP); ADENOSINE 5'-TRIPHOSPHATE; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
118
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Morris et al., "ROLES OF PEPTIDES AND OTHER SUBSTANCES IN COTRANSMISSION FROM VASCULAR AUTONOMIC AND SENSORY NEURONS", Canadian journal of physiology and pharmacology, 73(5), 1995, pp. 521-532

Abstract

Blood vessels may be innervated by up to three major classes of neurons: sympathetic vasoconstrictor neurons; sympathetic or parasympathetic vasodilator neurons; and peripheral fibres of small diameter sensoryneurons, which can mediate vasodilation. Most vascular neurons utilise multiple transmitters, including neuropeptides and small nonpeptidessuch as ATP or nitric oxide, often in addition to noradrenaline or acetylcholine. Subpopulations of each major class of vascular neurons innervating different vascular segments may contain different combinations of neurotransmitters. Furthermore, the same population of neurons can release different cotransmitters in response to different patterns of stimulation. In general, peptides mediate slower and more long lasting changes in vascular resistance than do nonpeptides. Thus, autonomic and sensory neurons are well adapted to produce qualitatively different vascular effects in response to different types of afferent input. The major challenge for the future is to develop new antagonists for many of the substances colocalised in vascular neurons, particularly neuropeptides. These agents will allow us to precisely determine the relative roles of multiple cotransmitters, and are likely to provide therapeutic agents that can be targeted to specific regions of the vasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:42:30