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Titolo:
SYNTHESIS AND IN-VITRO CYTOTOXICITY OF A SERIES OF 3-AMINOFLAVONES
Autore:
DAUZONNE D; FOLLEAS B; MARTINEZ L; CHABOT GG;
Indirizzi:
INST CURIE,CHIM LAB,CNRS UMR 176,SECT RECH,26 RUE ULM F-75231 PARIS 05 FRANCE INST GUSTAVE ROUSSY,LAB PHARMACOL CLIN,CNRS URA 147 F-94805 VILLEJUIFFRANCE
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 1, volume: 32, anno: 1997,
pagine: 71 - 82
SICI:
0223-5234(1997)32:1<71:SAICOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; FLAVONE ACETIC-ACID; INHIBITORS; CELLS; ANALOGS;
Keywords:
3-AMINOFLAVONE; 3-NITROFLAVONE; FLAVONE-8-ACETIC ACID ANALOG; L1210; ANTIPROLIFERATIVE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
D. Dauzonne et al., "SYNTHESIS AND IN-VITRO CYTOTOXICITY OF A SERIES OF 3-AMINOFLAVONES", European journal of medicinal chemistry, 32(1), 1997, pp. 71-82

Abstract

To further understand the molecular requirements for the antiproliferative activity of flavonoids, a series of 3-aminoflavones and some of their derivatives were prepared and evaluated using L1210 murine leukemia. Our novel five-step synthetic approach required easily available substituted aromatic aldehydes as starting materials and proved more convenient and more general than previously reported methods. Our results in the 3-aminoflavones series indicated that the 4'-methoxy group is important for cytotoxic activity. Moreover, for the flavone-8-aceticanalogs, a marked increase in potency was observed with the addition of a 3-amino or a 3-nitro group, Methoxy groups on the 6 and 7 positions of flavonoids (as in cirsiliol) also appear to be important for antiproliferative activity. These results are essential for the further understanding of the critical molecular requirements that lead to antiproliferative properties in the flavonoid series.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:08:00