Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MATERNAL SEPARATION REDUCES LATENT INHIBITION IN THE CONDITIONED TASTE-AVERSION PARADIGM
Autore:
ELLENBROEK BA; COOLS AR;
Indirizzi:
UNIV NIJMEGEN,DEPT PSYCHONEUROPHARMACOL,POB 9101 6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
Neuroscience research communications
fascicolo: 1, volume: 17, anno: 1995,
pagine: 27 - 33
SICI:
0893-6609(1995)17:1<27:MSRLII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA; AMPHETAMINE; STRESS; RATS;
Keywords:
ANIMAL MODELS; APOMORPHINE; GNAWING; INFORMATION PROCESSING; LATENT INHIBITION; MATERNAL SEPARATION; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Ellenbroek e A.R. Cools, "MATERNAL SEPARATION REDUCES LATENT INHIBITION IN THE CONDITIONED TASTE-AVERSION PARADIGM", Neuroscience research communications, 17(1), 1995, pp. 27-33

Abstract

Recent advances in the study of cognitive functioning and informationprocessing in schizophrenic patients have made it clear that these patients suffer from disturbances in selective attention, which can be measured, among others with the latent inhibition paradigm. Given the fact that there is increasing evidence that schizophrenia is a neurodevelopmental disorder and that early maternal separation leads to clear neurodevelopmental disturbances in rats we studied the effects of early maternal separation on the development of latent inhibition using the conditioned taste aversion paradigm. The results show that early maternal separation enhances the susceptibility of rats for the dopamine agonist apomorphine and at the same time disrupts the development of latent inhibition. Given the evidence of a critical role for the hippocampus in latent inhibition and the fact that this brain structure seems to be particularly sensitive to disturbances in the early postnatal phase, the early maternal separation paradigm may represent an interesting animal model for studying information processing disturbances in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:47:03