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Titolo:
GENETIC-VARIATION IN THE BETA(3)-ADRENERGIC RECEPTOR AND AN INCREASEDCAPACITY TO GAIN WEIGHT IN PATIENTS WITH MORBID-OBESITY
Autore:
CLEMENT K; VAISSE C; MANNING BS; BASDEVANT A; GUYGRAND B; RUIZ J; SILVER KD; SHULDINER AR; FROGUEL P; STROSBERG AD;
Indirizzi:
INST PASTEUR,CNRS,UNITE EP10,1 RUE CALMETTE,BP 245 F-59019 LILLE FRANCE INST PASTEUR,CNRS,UNITE EP10 F-59019 LILLE FRANCE UNIV HOSP LILLE LILLE FRANCE HOP HOTEL DIEU,DEPT NUTR F-75181 PARIS FRANCE INST COCHIN GENET MOLEC,IMMUNOPHARMACOL MOLEC LAB,CNRS,UNITE UPR 0415F-75014 PARIS FRANCE JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205
Titolo Testata:
The New England journal of medicine
fascicolo: 6, volume: 333, anno: 1995,
pagine: 352 - 354
SICI:
0028-4793(1995)333:6<352:GITBRA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-3-ADRENERGIC RECEPTOR; MOLECULAR CHARACTERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Clement et al., "GENETIC-VARIATION IN THE BETA(3)-ADRENERGIC RECEPTOR AND AN INCREASEDCAPACITY TO GAIN WEIGHT IN PATIENTS WITH MORBID-OBESITY", The New England journal of medicine, 333(6), 1995, pp. 352-354

Abstract

Background. The beta(3)-adrenergic receptor, located mainly in adipose tissue, is involved in the regulation of lipolysis and thermogenesis, The potential relevance of this receptor to obesity in humans led usto screen obese French patients for a recently identified mutation inthe gene for the receptor. Methods. We used the polymerase chain reaction to amplify a region of the gene for the beta(3)-adrenergic receptor encoding amino acid residues 27 to 110 in genomic DNA extracted from leukocytes from 185 patients with morbid obesity (body-mass index [the weight in kilograms divided by the square of the height in meters],>40) and 94 normal subjects. A mutation resulting in the replacement of tryptophan by arginine at position 64 (Trp64Arg) was detected by ananalysis of restriction-fragment-length polymorphisms with the use ofthe endonuclease BstNI, which discriminates between the normal and mutant sequences. Results. The frequency of the Trp64Arg allele was similar in the morbidly obese patients and the normal subjects (0.08 and 0.10, respectively), However, the patients with morbid obesity who wereheterozygous for the Trp64Arg mutation had an increased capacity to gain weight; the mean weight in the 14 heterozygous patients was 140 kg, as compared with 126 kg in the 171 patients without the mutation (P=0.03), There were no homozygotes in this sample, The cumulative 25-year change in weight (from the age of 20 years) was 67 kg in the Trp64Arg heterozygotes, as compared with 51 kg in those without the mutation. The maximal weight differential (the maximal lifetime weight minus the weight at 20 years of age) in the Trp64Arg heterozygotes was 74 kg, as compared with 59 kg in the patients without the mutation (P=0.02), Conclusions. People with the Trp64Arg mutation of the gene for the beta(3)-adrenergic receptor may have an increased capacity to gain weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:44:17