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Titolo:
EVIDENCE THAT THE AMYGDALA IS INVOLVED IN THE INHIBITORY EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON ALCOHOL-DRINKING IN RATS
Autore:
DYR W; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 4, volume: 12, anno: 1995,
pagine: 387 - 391
SICI:
0741-8329(1995)12:4<387:ETTAII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; 5-HT3-RECEPTOR ANTAGONISTS; RECOGNITION SITES; DOPAMINE RELEASE; ICS 205-930; HUMAN-BRAIN; ETHANOL; IDENTIFICATION; NUCLEUS; LINE;
Keywords:
5HT(3) RECEPTOR AND ETHANOL; 5-HT3 ANTAGONISTS; ETHANOL DRINKING; ONDANSETRON; TROPISETRON; AMYGDALA; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
W. Dyr e W. Kostowski, "EVIDENCE THAT THE AMYGDALA IS INVOLVED IN THE INHIBITORY EFFECTS OF 5-HT3 RECEPTOR ANTAGONISTS ON ALCOHOL-DRINKING IN RATS", Alcohol, 12(4), 1995, pp. 387-391

Abstract

Two 5-HT3 receptor antagonists, tropisetron (1 and 10 ng) and ondansetron (10 and 100 ng) were tested for effects on ethanol drinking in Wistar male rats after bilateral microinjection into the amygdala. The animals had limited access (2 h/day) to the 10% (v/v) ethanol solution,food and water were available ad lib during the scheduled access period. Both drugs caused a decrease in ethanol drinking. Tropisetron (1 and 10 ng) decreased ethanol intake during the first hour of access. The lower dose (10 ng) of ondansetron was more effective than the higher(100 ng) dose. The finding implicates amygdaloid 5-HT3 receptors in the mechanism of ethanol intake in Wistar rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:50:35