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Titolo:
RED-BLOOD-CELL VITAMIN-E CONCENTRATIONS IN FETUSES ARE RELATED TO BUTLOWER THAN THOSE IN MOTHERS DURING GESTATION - A POSSIBLE ASSOCIATIONWITH MATERNAL LIPOPROTEIN (A) PLASMA-LEVELS
Autore:
CACHIA O; LEGER CL; BOULOT P; VERNET MH; MICHEL F; DEPAULET AC; DESCOMPS B;
Indirizzi:
INSERM,CTR RECH,70 RUE NAVACELLES F-34090 MONTPELLIER FRANCE INSERM,CTR RECH F-34090 MONTPELLIER FRANCE INST BIOL MONTPELLIER MONTPELLIER FRANCE CHU MONTPELLIER,HOP LAPEYRONIE MONTPELLIER FRANCE
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 173, anno: 1995,
pagine: 42 - 51
SICI:
0002-9378(1995)173:1<42:RVCIFA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ALPHA-TOCOPHEROL; ERYTHROCYTE-MEMBRANES; LIQUID-CHROMATOGRAPHY; E-DEFICIENCY; ANTIOXIDANT; OXIDATION; RETINOL;
Keywords:
VITAMIN-E; FETUS; MOTHER; GESTATION; PLASMA LIPIDS; APOLIPOPROTEIN B; LIPOPROTEIN (A); RED BLOOD CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
O. Cachia et al., "RED-BLOOD-CELL VITAMIN-E CONCENTRATIONS IN FETUSES ARE RELATED TO BUTLOWER THAN THOSE IN MOTHERS DURING GESTATION - A POSSIBLE ASSOCIATIONWITH MATERNAL LIPOPROTEIN (A) PLASMA-LEVELS", American journal of obstetrics and gynecology, 173(1), 1995, pp. 42-51

Abstract

OBJECTIVE: The purpose was to establish which blood characteristics of vitamin E status were highly correlated between mothers and fetuses during gestation.STUDY DESIGN: Twenty-four pregnant women were selected because of suspicion of toxoplasmosis or other disease and malformation or intrauterine growth delay justifying cord blood puncture. Aftermaternal and fetal blood was collected, analyses of plasma and red blood cell vitamin E contents were performed together with analyses of standard lipid parameters and lipoprotein (a) in maternal plasma and fatty acid compositions of maternal and fetal red blood cells. RESULTS: The maternal population was characterized by a plasma lipid-normalizedvitamin E mean content higher (3.5 mmol/mol lipids) than usually found in nonpregnant adults. There was no relationship between plasma and red blood cell vitamin E contents. This was also true for fetuses. When the vitamin E status of mothers was compared with that of fetuses, we found no correlation in plasma vitamin E in the whole population andin the high lipoprotein (a) (>300 mg/L) and low lipoprotein (a) (<300mg/L) groups. In contrast, statistically significant correlations appeared between maternal and fetal red blood cell contents and red bloodcell relative charges in vitamin E in the whole population, whereas still higher correlations occurred in the high lipoprotein (a) group (r= 0.94 for the red blood cell content). Improved correlations were also found in the high lipoprotein (a) group for the interrelationship between vitamin E and plasma lipid contents (cholesterol and triglycerides), whereas improvement was noted in the low lipoprotein (a) group by positive correlation between age and vitamin E red blood cell content or red blood cell relative charge. CONCLUSION: Determination of red blood cell vitamin E and plasma lipoprotein (a) in mothers could be useful in antenatal blood analysis in cases of risk of prematurity at birth, to prevent peroxidative membrane damage in neonates, and >85% of the mothers in the current population would benefit from vitamin E supplementation from the viewpoint of the fetal red blood cell vitamin E requirement in spite of the rather high maternal lipid-normalized vitamin E plasma content.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:02:39