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Titolo:
ANTAGONISTS OF THE NMDA RECEPTOR-CHANNEL COMPLEX AND MOTOR COORDINATION
Autore:
CARTER AJ;
Indirizzi:
BOEHRINGER INGELHEIM KG,DEPT BIOL RES D-55216 INGELHEIM GERMANY
Titolo Testata:
Life sciences
fascicolo: 10, volume: 57, anno: 1995,
pagine: 917 - 929
SICI:
0024-3205(1995)57:10<917:AOTNRC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; MONOAMINE-DEPLETED MICE; AMINO-ACID ANTAGONISTS; SPINAL-CORD NEURONS; APPARENT ANXIOLYTIC PROPERTIES; PHENCYCLIDINE-LIKE CATALEPSY; MOUSE CENTRAL NEURONS; NUCLEUS-ACCUMBENS; DISSOCIATIVE ANESTHETICS; BEHAVIORAL PHARMACOLOGY;
Keywords:
NMDA; NMDA ANTAGONISTS; PHENCYCLIDINE; KETAMINE; MK-801; MOTOR COORDINATION; ATAXIA; PSYCHOSIS; MOTILITY; LOCOMOTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
160
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Carter, "ANTAGONISTS OF THE NMDA RECEPTOR-CHANNEL COMPLEX AND MOTOR COORDINATION", Life sciences, 57(10), 1995, pp. 917-929

Abstract

Many structurally different, centrally active antagonists of the NMDAreceptor-channel complex induce phencyclidine-like side effects in mammals which include head weaving, body rolling, sniffing and disturbances of motor coordination. The ability of these compounds to cause disturbances of motor coordination correlates directly with their abilityto antagonize the NMDA receptor-channel complex in vivo. Although noncompetitive antagonists increase motility in rodents, whereas competitive antagonists do not, both classes of compounds appear to induce schizophrenia-like psychosis in human beings, and cause similar changes in a variety of different biogenic amine neurotransmitter systems in the limbic and motoric areas of the brain. The complex spectrum of behavioural effects observed after the administration of antagonists of theNMDA receptor-channel complex probably reflects the intricate nature of the interaction with positive and negative feedback loops of the motor circuit. Recent research indicates that the site of integration ofthis interaction could be the striatal medium spiny GABAergic neuron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:13:17