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Titolo:
OUTCOME OF PATIENTS WITH BRAIN METASTASES AFTER COMBINED-MODALITY THERAPY IN SMALL-CELL LUNG-CANCER (SCLC) - A RETROSPECTIVE STUDY
Autore:
VESLEMES M; POLYZOS A; LATSI P; DIMITROULIS J; DIMAKOU K; JORDANOGLOU J;
Indirizzi:
20 AIGAIOU PELAGOUS GR-15341 ATHENS GREECE UNIV ATHENS,SOTIRIA HOSP,DEPT PULMONOL GR-11527 ATHENS GREECE
Titolo Testata:
Journal of chemotherapy
fascicolo: 5, volume: 7, anno: 1995,
pagine: 460 - 462
SICI:
1120-009X(1995)7:5<460:OOPWBM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
SMALL CELL LUNG CANCER; BRAIN RADIOTHERAPY; COMBINED MODALITY THERAPY; BRAIN METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M. Veslemes et al., "OUTCOME OF PATIENTS WITH BRAIN METASTASES AFTER COMBINED-MODALITY THERAPY IN SMALL-CELL LUNG-CANCER (SCLC) - A RETROSPECTIVE STUDY", Journal of chemotherapy, 7(5), 1995, pp. 460-462

Abstract

The authors evaluated the role of whole brain radiotherapy (WBRT) on the outcome of brain metastasis and survival in 41 patients with smallcell lung cancer (SCLC) treated in their department. In addition to chemotherapy, radiotherapy was given to the primary site in all responder patients. Six patients presented brain metastasis initially and 10 patients after the fourth course of chemotherapy. Brain metastases were symptomatic in 12 of 16 patients with a median time of 5 months (1-14) until symptoms developed. All patients but 2 with brain metastasis received WBRT (30 Gy in 10 fractions) in addition to chemotherapy. Themedian survival time of patients with brain metastasis was 8.3 months(3.5 to 16) compared to 12 months (4 to 34+) for patients without brain metastasis. In addition, the median survival time for patients withbrain metastasis who responded to systemic chemotherapy was better than that of nonresponders, The authors found no improvement in survivalin patients who received concomitant WBRT after chemotherapy comparedto patients who received WBRT after completion of chemotherapy. In conclusion, the role of consolidating cranial irradiation in addition tochemotherapy in SCLC patients is unclear and warrants prospective randomized studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:24:10