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Titolo:
THE IMMUNE-RESPONSE AND THE EYE - TCR ALPHA-CHAIN RELATED MOLECULES REGULATE THE SYSTEMIC IMMUNITY TO ANTIGEN PRESENTED IN THE EYE
Autore:
GRIFFITH TS; HERNDON JM; LIMA J; KAHN M; FERGUSON TA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT OPHTHALMOL & VISUAL SCI ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT OPHTHALMOL & VISUAL SCI ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110
Titolo Testata:
International immunology
fascicolo: 10, volume: 7, anno: 1995,
pagine: 1617 - 1625
SICI:
0953-8178(1995)7:10<1617:TIATE->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL-RECEPTOR; ANTERIOR-CHAMBER; DEVIATION ACAID; MONOCLONAL-ANTIBODY; INDUCTION; EXPRESSION; MICE; ENCEPHALOMYELITIS; IMMUNIZATION; SPECIFICITY;
Keywords:
EYE; IMMUNITY; TCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Griffith et al., "THE IMMUNE-RESPONSE AND THE EYE - TCR ALPHA-CHAIN RELATED MOLECULES REGULATE THE SYSTEMIC IMMUNITY TO ANTIGEN PRESENTED IN THE EYE", International immunology, 7(10), 1995, pp. 1617-1625

Abstract

Injection of antigen into the anterior chamber (AC) of the eye results in the induction of immune deviation in which antibody production isactivated and delayed-type hypersensitivity (DTH) is inhibited. This system is termed anterior chamber associated immune deviation (ACAID) and the model is used to examine certain aspects of the immunologic privilege of the eye. Recent studies have established that following antigen presentation in the eye, an 'ACAID-inducing' signal is produced that directly enters the blood. This signal then homes to the spleen where T cells that down-regulate DTH are activated. For many antigens this 'ACAID signal' is a soluble protein released within 2 days of AC injection. Although the presence of this molecule (or molecules) has been described using several antigens, the exact nature of the soluble mediator has escaped characterization. We have further explored the nature of this signal using HSV-1-induced immune deviation. Our results show the soluble 'signal' was released by T cells that encounter antigenin the ocular microenvironment. This mediator was antigen specific, contained TCR alpha-chain (but not the TCR beta-chain) determinants andhad an apparent molecular weight of 46 kDa. These results show that the release of soluble TCR alpha-chain from sites of T cell interactionwithin the microenvironment of the eye can regulate systemic immune responses. These results have implications for the control of immune response that might be damaging to organs such as the eye.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:48:20