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Titolo:
DECREASED INHIBITION TO LATERAL SUPERIOR OLIVE NEURONS IN YOUNG AND AGED SPRAGUE-DAWLEY RATS
Autore:
FINLAYSON PG;
Indirizzi:
UNIV BRITISH COLUMBIA,CTR ROTARY HEARING,DEPT SURG OTOLARYNGOL,2211 WESBROOK MALL,ROOM F-150 VANCOUVER BC V6T 2B5 CANADA
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 87, anno: 1995,
pagine: 84 - 95
SICI:
0378-5955(1995)87:1-2<84:DITLSO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNIT EXCITATORY RESPONSES; BINAURAL TONE BURSTS; INFERIOR COLLICULUS; TRAPEZOID BODY; MEDIAL NUCLEUS; COCHLEAR NUCLEUS; PRINCIPAL CELLS; CBA/J MICE; COMPLEX; CAT;
Keywords:
LATERAL SUPERIOR OLIVE; AGING; SPRAGUE-DAWLEY RAT; INHIBITORY DEFICITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Finlayson, "DECREASED INHIBITION TO LATERAL SUPERIOR OLIVE NEURONS IN YOUNG AND AGED SPRAGUE-DAWLEY RATS", Hearing research, 87(1-2), 1995, pp. 84-95

Abstract

Lateral superior olive (LSO) neurons in young and aged Sprague-Dawleyrats have functional properties consistent with a limited contralateral inhibition, which is markedly different from other animals. An unusually low proportion of LSO cells (36/113) exhibited contralateral inhibition (and ipsilateral excitation, IE), while over 25% of LSO units exhibited excitatory responses to contralateral stimuli. Inhibition ofmost IE LSO neurons was evident only when the contralateral intensitywas greater than the ipsilateral intensity, resulting in a marked shift in sensitivity to interaural intensity differences (IID). The firing rate of IE neurons was also affected more by a change in intensity of ipsilateral compared to contralateral stimuli. The shift in the IID sensitivity and the relative decrease in effectiveness of contralaterally driven inhibition in Sprague-Dawley rat LSO neurons could be due to decreased inhibitory inputs from the MNTB principal cells, increasedcontralateral excitatory effects and/or increased ipsilateral excitatory effects, Age-related decreases in the numbers of MNTB neurons observed anatomically is not reflected in a change in LSO function. The Sprague-Dawley rat may be a useful model for the effect of reduced inhibition in the superior olivary complex on auditory behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:13:32