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Titolo:
ASSESSMENT OF THE GENOTOXIC RISK FROM LAXATIVE SENNA PRODUCTS
Autore:
BRUSICK D; MENGS U;
Indirizzi:
CORNING HAZELTON INC,9200 LEESBURG TURNPIKE VIENNA VA 22182 MADAUS AG COLOGNE GERMANY
Titolo Testata:
Environmental and molecular mutagenesis
fascicolo: 1, volume: 29, anno: 1997,
pagine: 1 - 9
SICI:
0893-6692(1997)29:1<1:AOTGRF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALOE-EMODIN; SALMONELLA-TYPHIMURIUM; INTESTINAL BACTERIA; COLORECTAL-CANCER; RAT; MUTAGENICITY; CARCINOGENICITY; ANTHRAQUINONE; DERIVATIVES; HYDROXYANTHRAQUINONES;
Keywords:
SENNA; SENNOSIDES; ALOE-EMODIN; ANTHRAQUINONES; GENOTOXICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D. Brusick e U. Mengs, "ASSESSMENT OF THE GENOTOXIC RISK FROM LAXATIVE SENNA PRODUCTS", Environmental and molecular mutagenesis, 29(1), 1997, pp. 1-9

Abstract

Laxative senna products and several of their specific components havebeen submitted to a large number of genetic tests. While most studiesgave negative responses, results from some of the studies suggest that components of senna products, particularly emodin and aloe-emodin, have genotoxic activity. Assessment of the genotoxicity profile of these substances, in light of other data from animal and human metabolism or kinetic studies, human clinical trials and rodent carcinogenicity studies do not support concerns that senna laxatives pose a genotoxic risk to humans when consumed under prescribed use conditions. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:07:36