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Titolo:
EFFECT OF ENDOGENOUS HYPERGASTRINEMIA ON GASTRIN RECEPTOR-EXPRESSING HUMAN COLON-CARCINOMA TRANSPLANTED TO ATHYMIC RATS
Autore:
CHU M; NIELSEN FC; FRANZEN L; REHFELD JF; HOLST JJ; BORCH K;
Indirizzi:
LINKOPING UNIV HOSP,DEPT SURG S-58185 LINKOPING SWEDEN LINKOPING UNIV HOSP,DEPT SURG S-58185 LINKOPING SWEDEN LINKOPING UNIV HOSP,DEPT PATHOL S-58185 LINKOPING SWEDEN UNIV COPENHAGEN,DEPT CLIN BIOCHEM COPENHAGEN DENMARK UNIV COPENHAGEN,DEPT MED PHYSIOL COPENHAGEN DENMARK
Titolo Testata:
Gastroenterology
fascicolo: 5, volume: 109, anno: 1995,
pagine: 1415 - 1420
SICI:
0016-5085(1995)109:5<1415:EOEHOG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATES GROWTH; LIVER METASTASIS; INVITRO GROWTH; CANCER; MUCOSA; PENTAGASTRIN; CELLS; NUDE; GLICENTIN; PANCREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Chu et al., "EFFECT OF ENDOGENOUS HYPERGASTRINEMIA ON GASTRIN RECEPTOR-EXPRESSING HUMAN COLON-CARCINOMA TRANSPLANTED TO ATHYMIC RATS", Gastroenterology, 109(5), 1995, pp. 1415-1420

Abstract

Background & Aims: The effect of endogenous hypergastrinemia on growth of human colon carcinoma is not known. Our aim was to study the growth of human colon carcinoma in an animal model with endogenous hypergastrinemia. Methods: Human colon carcinoma was transplanted to the colon of 40 athymic rats. Of these, 25 underwent gastric fundectomy to accomplish endogenous hypergastrinemia, and 15 were sham operated to serve as controls. The duration of the study was 8 weeks. During the last week, 12 fundectomized animals received a gastrin (cholecystokinin B) receptor antagonist. Metaphase arrest index, local invasion, and distant spread of the tumor were investigated. Expression of gastrin and cholecystokinin B receptor messenger RNA was examined by reverse transcription polymerase chain reaction. Results: Tumor spread by direct extension outside the colon was observed in all animals, and liver metastases were observed in 10 of the 25 fundectomized animals. Sham-operatedanimals showed none of these features. The metaphase arrest index of the tumor did not differ between fundectomized animals given the cholecystokinin B receptor antagonist and sham-operated animals, whereas itwas significantly increased in fundectomized animals not given the antagonist. The tumor expressed both gastrin and cholecystokinin B receptor messenger RNA. Conclusions: The results indicate that endogenous hypergastrinemia may promote proliferation and spread of human colon carcinoma expressing cholecystokinin B receptor.

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Documento generato il 28/11/20 alle ore 00:12:28