Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CORRECTION OF GLUCOSE-CONCENTRATION INTERFERENCE ON JAFFE KINETIC CREATININE ASSAY IN PERITONEAL-DIALYSIS
Autore:
DARIN G; AMICI G; VIRGA G; BARDIN C; CALZAVARA P; BOCCI C;
Indirizzi:
REG HOSP S MARIA DEI BATTUTI,INST CLIN CHEM I-31100 TREVISO ITALY REG HOSP S MARIA DEI BATTUTI,DIV NEPHROL & DIALYSIS I-31100 TREVISO ITALY
Titolo Testata:
American journal of nephrology
fascicolo: 6, volume: 15, anno: 1995,
pagine: 480 - 487
SICI:
0250-8095(1995)15:6<480:COGIOJ>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Keywords:
PERITONEAL DIALYSIS; CREATININE; JAFFE KINETIC ASSAY; ENZYMATIC ASSAY; GLUCOSE INTERFERENCE; CORRECTION FORMULAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G. Darin et al., "CORRECTION OF GLUCOSE-CONCENTRATION INTERFERENCE ON JAFFE KINETIC CREATININE ASSAY IN PERITONEAL-DIALYSIS", American journal of nephrology, 15(6), 1995, pp. 480-487

Abstract

Overestimation of creatinine measurement using the Jaffe kinetic method in peritoneal dialysis solutions, due to glucose interference, has been quantified and corrected through the elaboration of linear formulas obtained from 110 recovery and 301 biological tests. The added purepowdered creatinine and enzymatic method were considered as references after proven accuracy. Considering creatinine as well as glucose concentration interference, we obtained correction formulas from multipleregression application, All the computed formulas gave satisfactory corrections but different accuracy levels. The best model in biologicalsamples was: Corrected CR = K(1)JaffeCr + K(2)Glucose (all values in mg/dl) where K-1 = 0.973 and K-2 = -0.00035 (Rsq = 0.987, F ratio 10,945, p = 0.00001). Applying formulas to biological samples there was a drop in accuracy, possibly explained by the presence of numerous unidentified substances in peritoneal dialysis biological samples that can amplify scatter. Every laboratory can reduce the error of the Jaffe kinetic assay by calculating their own correction formula in relation tothe method and instrument used, because Jaffe kinetic assay gives different results with different kinetic windows. So, especially when applied to peritoneal dialysis fluid measurements, if a creatinine assay reference method is not available, the correction formula can be applied directly as given. Otherwise the method we have described can be followed with a well-structured creatinine recovery fest to identify andquantify assay interferences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:01:53