Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
T-CELLS, BUT NOT B-CELLS, ARE REQUIRED FOR BOWEL INFLAMMATION IN INTERLEUKIN 2-DEFICIENT MICE
Autore:
MA A; DATTA M; MARGOSIAN E; CHEN JZ; HORAK I;
Indirizzi:
HARVARD UNIV,SCH MED,CTR BLOOD RES,ALPERT 156,200 LONGWOOD AVE BOSTONMA 02115 CHILDRENS HOSP BOSTON MA 02115 BETH ISRAEL HOSP BOSTON MA 02115 BRIGHAM & WOMENS HOSP BOSTON MA 02115 UNIV WURZBURG,INST VIROL & IMMUNOBIOL D-97078 WURZBURG GERMANY
Titolo Testata:
The Journal of experimental medicine
fascicolo: 5, volume: 182, anno: 1995,
pagine: 1567 - 1572
SICI:
0022-1007(1995)182:5<1567:TBNBAR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INTESTINAL INFLAMMATION; RECEPTOR MUTANT MICE; GENE; REARRANGEMENT; LYMPHOCYTES; DEFICIENT; DISEASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Ma et al., "T-CELLS, BUT NOT B-CELLS, ARE REQUIRED FOR BOWEL INFLAMMATION IN INTERLEUKIN 2-DEFICIENT MICE", The Journal of experimental medicine, 182(5), 1995, pp. 1567-1572

Abstract

Interleukin-2 (IL-2)-deficient (IL-2(-/-)) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2(-/-) mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2(-/-), lacking B and T cells) and JH-deficient mice (JH(-/-), lacking B cells). IL-2(-/-), RAG-2(-/-) double-mutant mice are disease free, while IL-2(-/-), JH(-/-) double-mutant micesuccumb to bowel disease at the same rate as IL-2(-/-) littermates. IL-2(-/-), JH(-/-) mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2(-/-) mice requires mature T cells, not B cells, while anemia is dependent on B cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:09:18