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Titolo:
DETECTION OF TUMOR-ASSOCIATED ANTIGENS IN SERA OF CANINE CANCER-PATIENTS BY MONOCLONAL-ANTIBODIES GENERATED AGAINST CANINE MAMMARY-CARCINOMA CELLS
Autore:
WANG JY; BRUNNER CJ; GANGOPADHYAY A; BIRD AC; WOLFE LG;
Indirizzi:
AUBURN UNIV,COLL VET MED,DEPT PATHOBIOL AUBURN AL 36849 AUBURN UNIV,COLL VET MED,DEPT PATHOBIOL AUBURN AL 36849
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3-4, volume: 48, anno: 1995,
pagine: 193 - 207
SICI:
0165-2427(1995)48:3-4<193:DOTAIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE POLYPEPTIDE ANTIGEN; BREAST-CANCER; CARCINOEMBRYONIC ANTIGEN; IMMUNOHISTOCHEMICAL EVALUATION; CLINICAL-APPLICATIONS; COLORECTAL-CARCINOMA; CA 72-4; MARKERS; EXPRESSION; DIAGNOSIS;
Keywords:
CANINE; MAMMARY CANCER; CARCINOMA; MONOCLONAL ANTIBODY; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); TUMOR-ASSOCIATED ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.Y. Wang et al., "DETECTION OF TUMOR-ASSOCIATED ANTIGENS IN SERA OF CANINE CANCER-PATIENTS BY MONOCLONAL-ANTIBODIES GENERATED AGAINST CANINE MAMMARY-CARCINOMA CELLS", Veterinary immunology and immunopathology, 48(3-4), 1995, pp. 193-207

Abstract

Two murine monoclonal antibodies (MAbs), 1A10 and SB2, generated against a canine mammary carcinoma cell line, were used in a competitive enzyme-linked immunosorbent assay (ELISA) to measure tumor-associated antigens (TAAs) in canine serum samples. Sera were tested from disease-free dogs and from dogs diagnosed with mammary carcinoma, non-mammary carcinoma, sarcoma, benign mammary tumor, benign non-mammary tumor, ornon-neoplastic disease. Serum antigen concentrations measured by ELISA were expressed as inhibitory units (IU). The upper limit of normal, defined as the mean plus 2 SD of the TAA concentration in disease-freedogs, was 20 IU with antibody 1A10 and 22 IU with antibody SB2. Compared with disease-free dogs, the frequency of TAA-positive sera was significantly greater (P < 0.05) among dogs with mammary or non-mammary carcinoma when tested with MAbs 1A10 or SB2, and also with sarcoma whentested with MAb SB2. Testing a serum sample with both antibodies rather than just one increased the sensitivity of the competitive ELISA for TAA detection. The presence of TAA in serum might serve as a useful marker for certain types of carcinomas or sarcomas in canine cancer patients.

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Documento generato il 31/10/20 alle ore 00:38:02