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Titolo:
AUTOMATED-DETERMINATION OF TRIMIPRAMINE AND N-DESMETHYLTRIMIPRAMINE IN HUMAN PLASMA OR SERUM BY HPLC WITH ONLINE SOLID-PHASE EXTRACTION
Autore:
HARTTER S; HERMES B; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY
Titolo Testata:
Journal of liquid chromatography
fascicolo: 17, volume: 18, anno: 1995,
pagine: 3495 - 3505
SICI:
0148-3919(1995)18:17<3495:AOTANI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; ANTIDEPRESSANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S. Hartter et al., "AUTOMATED-DETERMINATION OF TRIMIPRAMINE AND N-DESMETHYLTRIMIPRAMINE IN HUMAN PLASMA OR SERUM BY HPLC WITH ONLINE SOLID-PHASE EXTRACTION", Journal of liquid chromatography, 18(17), 1995, pp. 3495-3505

Abstract

A fully automated method including column-switching and isocratic high performance liquid chromatography (HPLC) was developed for determination of the tricyclic antidepressant trimipramine (T) and its N-demethylated metabolite N-desmethyltrimipramine (DT). The limit of quantification was below 10 ng/ml For T and DT. The assay revealed linearity between detector response and drug concentration in a therapeutically relevant range of 10 to 500 ng/ml. The mean intra- and interassay variabilities were 6.2 and 12.3%, respectively, for T and 4.7 and 8.7%,respectively, for DT. The method can be applied to therapeutic drug monitoring of patients under T therapy and may be useful for pharmacokinetic studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:56:23