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Titolo:
CHRONIC INFUSION OF A CRH(1) RECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDE INTO THE CENTRAL NUCLEUS OF THE AMYGDALA REDUCED ANXIETY-RELATED BEHAVIOR IN SOCIALLY DEFEATED RATS
Autore:
LIEBSCH G; LANDGRAF R; GERSTBERGER R; PROBST JC; WOTJAK CT; ENGELMANN M; HOLSBOER F; MONTKOWSKI A;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,KRAEPELINSTR 2 D-80804 MUNICH GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN D-80804 MUNICH GERMANY MAX PLANCK INST PHYSIOL & CLIN RES D-62123 BAD NAUHEIM GERMANY
Titolo Testata:
Regulatory peptides
fascicolo: 2, volume: 59, anno: 1995,
pagine: 229 - 239
SICI:
0167-0115(1995)59:2<229:CIOACR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CENTRAL NERVOUS-SYSTEM; FACTOR CRF; EXPLORATORY-BEHAVIOR; HORMONE-SECRETION; FACTOR ANTAGONIST; STRESS; IMMUNONEUTRALIZATION; WITHDRAWAL; BLOCKADE;
Keywords:
PLUS-MAZE; SOCIAL RECOGNITION; RECEPTOR AUTORADIOGRAPHY; IN SITU HYBRIDIZATION; ANTISENSE TARGETING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
G. Liebsch et al., "CHRONIC INFUSION OF A CRH(1) RECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDE INTO THE CENTRAL NUCLEUS OF THE AMYGDALA REDUCED ANXIETY-RELATED BEHAVIOR IN SOCIALLY DEFEATED RATS", Regulatory peptides, 59(2), 1995, pp. 229-239

Abstract

We studied the role of central amygdala CRH receptors in behavioral responses to an anxiogenic stimulus. An antisense oligodeoxynucleotide corresponding to the rat CRH(1) receptor mRNA was infused chronically into the central amygdaloid nucleus of male rats via osmotic minipumps(0.25 mu g/0.5 mu l/h). Control groups received infusions of either ascrambled sequence oligodeoxynucleotide or vehicle. On the 4th day oftreatment, rats were subjected to 10 min of social defeat and immediately afterwards tested on the elevated plus-maze. Antisense oligodeoxynucleotide-treated rats spent significantly more time exploring the open arms of the plus-maze than scrambled sequence- and vehicle-treated animals, both of which did not differ from each other. The social discrimination test, on the other hand, revealed no difference in juvenilerecognition abilities among the treatment groups. Using in situ hybridization and receptor autoradiography, we were not able to detect clear signals of CRH(1) receptor mRNA and CRH binding sites in the centralamygdaloid nucleus of either group, confirming the reportedly low expression and density of CRH receptors in this brain area. The present data support the view that CRH receptors in the central nucleus of the amygdala are involved in the mediation and expression of anxiety-related behavior, but simultaneously raise questions as to the mechanisms of antisense oligodeoxynucleotide action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:57:08