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Titolo:
MONOCLONAL PROLIFERATION OF CD4(+) LARGE GRANULAR LYMPHOCYTES WITH CYTOLYTIC ACTIVITY
Autore:
YASUKAWA M; UTSUNOMIYA Y; INOUE Y; KIMURA N; FUJITA S;
Indirizzi:
EHIME UNIV,SCH MED,DEPT INTERNAL MED 1 SHIGENOBU EHIME 79102 JAPAN FUKUOKA UNIV,SCH MED,DEPT INTERNAL MED 1 FUKUOKA 81401 JAPAN
Titolo Testata:
British Journal of Haematology
fascicolo: 2, volume: 91, anno: 1995,
pagine: 419 - 420
SICI:
0007-1048(1995)91:2<419:MPOCLG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; EXPRESSION; DISORDERS; PERFORIN;
Keywords:
LARGE GRANULAR LYMPHOCYTE; CD4(+); MONOCLONAL PROLIFERATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
M. Yasukawa et al., "MONOCLONAL PROLIFERATION OF CD4(+) LARGE GRANULAR LYMPHOCYTES WITH CYTOLYTIC ACTIVITY", British Journal of Haematology, 91(2), 1995, pp. 419-420

Abstract

A rare case of monoclonal proliferation of CD3(+)4(+)8(-) T-cell receptor-alpha beta(+) large granular lymphocytes (LGL) is presented. CD4() LGL in the present case showed spontaneous cytotoxicity against herpes simplex virus-infected cells and antibody- and lectin-dependent cytotoxicity. Perforin, which is one of the important cytolytic mediators of cytotoxic T cells (CTL) and natural killer cells, was abundantly expressed in CD4(+) LGL of this case. The present case suggests that perforin-positive CD4(+) CTL, which have recently been shown in the in vitro studies, certainly exist in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:04:40