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Titolo:
PLATELET ACTIVATION
Autore:
BLOCKMANS D; DECKMYN H; VERMYLEN J;
Indirizzi:
CATHOLIC UNIV LEUVEN,DEPT INTERNAL MED B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LEUVEN,CTR MOLEC & VASC BIOL B-3000 LOUVAIN BELGIUM
Titolo Testata:
Blood reviews
fascicolo: 3, volume: 9, anno: 1995,
pagine: 143 - 156
SICI:
0268-960X(1995)9:3<143:PA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; HUMAN-BLOOD PLATELETS; GEL-FILTERED PLATELETS; SIGNAL TRANSDUCTION; SHAPE-CHANGE; ADENYLATE-CYCLASE; MYELOPROLIFERATIVE DISORDERS; PROSTAGLANDIN-D2 RECEPTORS; DEPENDENT PHOSPHORYLATION; MYOSIN PHOSPHORYLATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
124
Recensione:
Indirizzi per estratti:
Citazione:
D. Blockmans et al., "PLATELET ACTIVATION", Blood reviews, 9(3), 1995, pp. 143-156

Abstract

This review article describes the different receptors, second-messengers and mechanisms involved in platelet activation. Several platelet agonists have well-defined receptors at the platelet membrane of which a number are single polypeptides with 7 hydrophobic transmembrane domains. These receptors are connected, via GTP regulatory proteins, with cytoplasmic second-messenger-generating enzymes. Phospholipase C and adenylate cyclase are the two best-known enzymes, generating inositol triphosphate (IP3) and diacyl glycerol from phosphatidylinositol biphosphate and cyclic AMP from ATP respectively. The intraplatelet free calcium level, which is critical for the activation status of the platelet, is increased by IP3 and is lowered in the presence of rising cyclicAMP concentrations, Shape-change occurs with small increases in intraplatelet calcium, while aggregation and secretion of granules take place at higher calcium levels. The role of myosin and actin filaments and of transmembrane glycoproteins is further discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:39:24