Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERACTION OF THE DOPAMINERGIC AND SEROTONERGIC SYSTEMS IN THE RAT STRIATUM - EFFECTS OF SELECTIVE ANTAGONISTS AND UPTAKE INHIBITORS
Autore:
WONG PTH; FENG H; TEO WL;
Indirizzi:
NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,10 KENT RIDGE CRESCENT SINGAPORE 0511 SINGAPORE
Titolo Testata:
Neuroscience research
fascicolo: 1, volume: 23, anno: 1995,
pagine: 115 - 119
SICI:
0168-0102(1995)23:1<115:IOTDAS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED BENZAMIDE; H-3 ETICLOPRIDE; CONSCIOUS RATS; BRAIN; RELEASE; RECEPTORS; INVIVO; BINDING; MICRODIALYSIS; 5-HYDROXYTRYPTAMINE;
Keywords:
DOPAMINE; 5-HYDROXYTRYPTAMINE; ETICLOPRIDE; NOMIFENSINE; MIANSERIN; CITALOPRAM; AUTORECEPTORS; HETERORECEPTORS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P.T.H. Wong et al., "INTERACTION OF THE DOPAMINERGIC AND SEROTONERGIC SYSTEMS IN THE RAT STRIATUM - EFFECTS OF SELECTIVE ANTAGONISTS AND UPTAKE INHIBITORS", Neuroscience research, 23(1), 1995, pp. 115-119

Abstract

The effects of some selective dopamine (DA) and 5-hydroxytryptamine (5-HT) antagonists and uptake inhibitors on the outflow of homovanillicacid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum were studied using microdialysis in conscious rats. Eticlopride (D-2 antagonist, 2.5 mg/kg) increased HVA but decreased 5-HIAA, while nomifensine (DA uptake inhibitor, 10 mg/kg) decreased both. Mianserin (5-HT2 antagonist, 2 mg/kg) and citalopram (5-HT uptake inhibitor, 11 mg/kg) also decreased both HVA and 5-HIAA. The selectivity of these drugs and the time course of their effects on HVA and 5-HIAA suggested that the dopaminergic drugs may affect the serotonergic systems primarily via changes in extraneuronal DA and conversely, serotonergic drugs affect the dopaminergic systems via changes in extraneuronal 5-HT. The resultsobtained are consistent with current evidence that DA and 5-HT release from striatal terminals are regulated by D-2 and 5-HT1B autoreceptors, respectively. They also support the idea that, in the rat striatum,presynaptic inhibitory heteroreceptors are a major mechanism that contributes to a reciprocal interaction of the dopaminergic and serotonergic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:37:26