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Titolo:
A NOVEL FACTOR, TA20, INVOLVED IN NEURONAL DIFFERENTIATION - CDNA CLONING AND EXPRESSION
Autore:
TOHDA C; NAGAI S; TOHDA M; NOMURA Y;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL SAPPORO HOKKAIDO 060 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT NEUROSCI TOYAMAJAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DIV PHARMACOL TOYAMAJAPAN
Titolo Testata:
Neuroscience research
fascicolo: 1, volume: 23, anno: 1995,
pagine: 21 - 27
SICI:
0168-0102(1995)23:1<21:ANFTII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; GLIOMA HYBRID-CELLS; NG108-15 CELLS; SYNAPSE FORMATION; PHORBOL ESTER; TRANSCRIPTION FACTOR; SIGNAL-TRANSDUCTION; NEURITE FORMATION; PC12 CELLS; PROLIFERATION;
Keywords:
NEURONAL DIFFERENTIATION; CDNA CLONING; DIFFERENTIAL SCREENING; NEURITE EXTENSION; TRANSFECTION; NG108-15 CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Tohda et al., "A NOVEL FACTOR, TA20, INVOLVED IN NEURONAL DIFFERENTIATION - CDNA CLONING AND EXPRESSION", Neuroscience research, 23(1), 1995, pp. 21-27

Abstract

Combined treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) and dibutyryl cyclic AMP (diBu-cAMP) induced significantly longer neurites than treatment with each alone in NG108-15 cells. We performed differential screening to identify genes expressed only by treatment with TPA plus diBu-cAMP but not by that with diBu-cAMP for 72 h alone in NG108-15 cells, and isolated a novel gene, TA20. Over-expression of the gene in NG108-15 and neuroblastoma N18TG-2 cells caused intense neurite elongation and suppressed cell growth. TA20 did not cause, however, any morphological changes in glioma C6Bu-1 cells. These results suggest that TA20 is a novel neuronal differentiation factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:06:04