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Titolo:
ISLET-CELL TUMORS OF THE PANCREAS - PATHOLOGICAL-IMAGING CORRELATION AMONG SIZE, NECROSIS AND CYSTS, CALCIFICATION, MALIGNANT BEHAVIOR, ANDFUNCTIONAL STATUS
Autore:
BUETOW PC; PARRINO TV; BUCK JL; PANTONGRAGBROWN L; ROS PR; DACHMAN AH; CRUESS DF;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,BLDG 54,RM M-121,ALASKA AVE & FEM ST NW WASHINGTON DC 20306 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL BETHESDA MD 20814 UNIFORMED SERV UNIV HLTH SCI,DEPT NUCL MED BETHESDA MD 20814 NATL NAVAL MED RES INST,DEPT RADIOL BETHESDA MD 20814 UNIV FLORIDA,DEPT RADIOL GAINESVILLE FL 32610 UNIV CHICAGO,DEPT RADIOL CHICAGO IL 60637 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED BETHESDA MD 20814
Titolo Testata:
American journal of roentgenology
fascicolo: 5, volume: 165, anno: 1995,
pagine: 1175 - 1179
SICI:
0361-803X(1995)165:5<1175:ITOTP->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOCRINE TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Buetow et al., "ISLET-CELL TUMORS OF THE PANCREAS - PATHOLOGICAL-IMAGING CORRELATION AMONG SIZE, NECROSIS AND CYSTS, CALCIFICATION, MALIGNANT BEHAVIOR, ANDFUNCTIONAL STATUS", American journal of roentgenology, 165(5), 1995, pp. 1175-1179

Abstract

OBJECTIVE. The purpose of our study was to correlate the imaging and pathologic features of islet cell tumors with regard to tumor size, necrosis and cysts, calcification, malignant behavior, and functional status. MATERIALS AND METHODS. We retrospectively reviewed the clinical,pathologic, and imaging features of all 133 cases of pathologically proved islet cell tumors of the pancreas seen at the Armed Forces institute of Pathology, Clinical data, including the patients' symptoms andserologic characteristics, were used to distinguish hyperfunctioning tumors (those causing symptoms related to elevated serum polypeptide levels) from nonhyper-functioning tumors; hyperfunctioning tumors were divided further into insulin-producing and non-insulin-producing types. All patients had at least one cross-sectional imaging study, including CT (n = 118), sonography (n = 42), or MR imaging (n = 22). Clinical, pathologic, and imaging features were evaluated and correlated with tumor size, necrosis and cysts, calcification, local invasion, vascular invasion, metastases, and functional status. RESULTS. Islet cell tumors with areas of necrosis or cystic change found pathologically and on imaging studies (56/133) were larger (8.4 cm in mean transverse diameter) than homogeneous solid lesions (2.9 cm in mean transverse diameter) and were predominantly non-insulin producing (48/56) and nonhyperfunctioning (36/56). Of the 43 insulinomas, 35 were small (2.2 cm in mean transverse diameter), solid, and homo-geneous. Larger size also wasassociated with calcification and malignant behavior, including localinvasion, vascular invasion, and distant metastases. CONCLUSION. Our findings show that cystic and necrotic islet cell tumors are usually non-insulin-producing and nonhyperfunctioning neoplasms and larger thanthe typically solid and small insulinomas. Calcification, local invasion, vascular invasion, and metastatic disease are more commonly seen with larger neoplasms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 13:49:12