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Titolo:
ASEPTIC LOOSENING IN UNCEMENTED TOTAL HIP-ARTHROPLASTY IN A CANINE MODEL
Autore:
DOWD JE; SCHWENDEMAN LJ; MACAULAY W; DOYLE JS; SHANBHAG AS; WILSON S; HERNDON JH; RUBASH HE;
Indirizzi:
UNIV PITTSBURGH,MED CTR,DEPT ORTHOPAED SURG,MUSCULOSKELATAL RES CTR,KAUFMANN BLDG,SUITE 1010 PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,DEPT ORTHOPAED SURG,MUSCULOSKELATAL RES CTR PITTSBURGH PA 15213
Titolo Testata:
Clinical orthopaedics and related research
fascicolo: 319, , anno: 1995,
pagine: 106 - 121
SICI:
0009-921X(1995):319<106:ALIUTH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNOVIAL-LIKE MEMBRANE; BONE-CEMENT INTERFACE; TISSUE-CULTURE; INTERLEUKIN-1; RESORPTION; REPLACEMENT; PARTICLES; JOINT; WEAR; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Dowd et al., "ASEPTIC LOOSENING IN UNCEMENTED TOTAL HIP-ARTHROPLASTY IN A CANINE MODEL", Clinical orthopaedics and related research, (319), 1995, pp. 106-121

Abstract

An in vivo canine model was developed to investigate the histologic and biochemical parameters associated with aseptic loosening. Thirty-eight canines had cementless total hip arthroplasty. Experimental groupswere designed specifically to investigate the relative contributions of implant motion and particulate debris (cobalt chrome alloy, titanium aluminum vanadium, and polyethylene) on the resultant periprosthetictissues. Tissues from a stable, well-ingrown prosthesis provided a control. Importantly the histologic and biochemical characteristics of the experimentally induced membranes consistently correlated with previous in vitro reports of tissues retrieved at revision surgery for aseptic loosening. Implant motion and all 3 particulate debris groups resulted in increased numbers of macrophages in the periprosthetic membranes. The histologic findings paralleled the increase in levels of biochemical mediators of bone resorption as measured by collagenase, gelatinase, prostaglandin E(2), and interleukin-1 activity. The most striking results were seen in the histology and biochemistry of the particle groups with highly cellular membranes showing increased biochemical activity when compared with controls. The clinical relevance of this work lies in the description of an in vivo model of aseptic loosening that can be used to investigate the effects of numerous variables implicated in aseptic loosening, Ultimately, the model may serve as a basis for developing therapeutic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:25:47