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Titolo:
DEVELOPMENT AND REGULATION OF PORCINE PANCREATIC FUNCTION
Autore:
PIERZYNOWSKI SG; WESTROM BR; SVENDSEN J; SVENDSEN L; KARLSSON BW;
Indirizzi:
LUND UNIV,DEPT ANIM PHYSIOL,HELGONAVAGEN 3B S-22362 LUND SWEDEN SWEDISH UNIV AGR SCI,DEPT AGR BIOSYST & TECHNOL LUND SWEDEN
Titolo Testata:
International journal of pancreatology
fascicolo: 2, volume: 18, anno: 1995,
pagine: 81 - 94
SICI:
0169-4197(1995)18:2<81:DAROPP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROCOLIPASE ACTIVATION PEPTIDE; INHIBITS INSULIN-SECRETION; MESSENGER-RNA LEVELS; EXOCRINE PANCREAS; ANTIBACTERIAL ACTIVITY; ENZYME SECRETION; FEEDBACK-REGULATION; GENE-EXPRESSION; PRO-COLIPASE; RAT PANCREAS;
Keywords:
PIG; PANCREAS; WEANING; INSULIN; CCK; SECRETIN; MILK; ANTIBACTERIAL ACTIVITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Pierzynowski et al., "DEVELOPMENT AND REGULATION OF PORCINE PANCREATIC FUNCTION", International journal of pancreatology, 18(2), 1995, pp. 81-94

Abstract

A surgical and experimental procedure was developed to enable the collection of pure and inactivated pancreatic juice during the growth of the pig. Studies have shown that, during the suckling period, both thebasal and the secretory responses to suckling are low, if present at all. After weaning, basal levels of the total exocrine secretion, total protein, amylase, and trypsin, respectively, increase slightly, while the postprandial levels of total protein, amylase, trypsin, lipase, colipase, and carboxylester lipase, respectively, increase markedly. The pancreatic juice enzyme composition changes qualitatively and the antibacterial activity of the pancreatic juice also significantly increases. Piglet age appeared to be of minor importance, since weaning at either 4 or 6 wk of age gave the same results. Secretin and CCK administered together in supraphysiological doses only significantly affect exocrine function from 3-4 wk of age. However, CCK may also affect theexocrine pancreas indirectly via reflexes initiated intraduodenally. Milk consumption in the suckling pig leads to a postprandial increase in glucose levels but not insulin. Milk appears to be able to regulatethe exocrine pancreas to produce only the amount and type of enzymes required for digestion. Thus, milk components or digestive products may affect pancreas function regulation. Studies show that enterostatin,the procolipase activation peptide, may inhibit pancreatic secretion mediated indirectly through the GI tract. Pancreastatin, an endocrine peptide, inhibits both insulin secretion and protein and trypsin secretion to pancreatic juice. In hypoinsulinemic (alloxan + streptozotocindiabetes) pigs (15-20 kg), no postprandial pancreatic juice response is seen, although CCK 33 + secretin can stimulate pancreatic secretion. Hypoinsulinemic pigs have a reduced capacity for glucose tissue utilization, suggesting that tissue metabolism and exocrine pancreas secretion are related.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 03:35:48