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Titolo:
GREATER DIVERSITY OF HEPATITIS-C VIRUS GENOTYPES FOUND IN HONG-KONG THAN IN MAINLAND CHINA
Autore:
ZHANG YY; LOK ASF; CHAN DTM; WIDELL A;
Indirizzi:
LUND UNIV,MALMO HOSP,DEPT MED MICROBIOL S-20505 MALMO SWEDEN LUND UNIV,MALMO HOSP,DEPT MED MICROBIOL S-20502 MALMO SWEDEN QUEEN MARY HOSP,DEPT MED HONG KONG HONG KONG VET ADM MED CTR NEW ORLEANS LA 70146 TULANE UNIV NEW ORLEANS LA 70118
Titolo Testata:
Journal of clinical microbiology
fascicolo: 11, volume: 33, anno: 1995,
pagine: 2931 - 2934
SICI:
0095-1137(1995)33:11<2931:GDOHVG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; SEQUENCE-ANALYSIS; REGION; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y.Y. Zhang et al., "GREATER DIVERSITY OF HEPATITIS-C VIRUS GENOTYPES FOUND IN HONG-KONG THAN IN MAINLAND CHINA", Journal of clinical microbiology, 33(11), 1995, pp. 2931-2934

Abstract

A hepatitis C virus (HCV) genotyping PCR assay based on type-specificprimers was expanded to include genotype 6a as well as genotypes 1a, 1b, 2a, 2b, and 3a. The nucleotide sequences of a 194-bp fragment in the center of the HCV core gene showed that the homologies between genotype 6a and genotypes 1a, 1b, 2a, 2b, 3a, and 5 were 81.2, 82.1, 73.8,77.3, 81.4, and 78.9%, respectively. A high degree of homology (99.6%) was seen in the amplified core region among eight clinically unrelated genotype 6a isolates. Although the Hong Kong Chinese patients had predominantly genotype 1b (70%), it was noteworthy that genotype 6a wasthe second most common genotype (14%). Four other HCV genotypes-1a, 1b, 2a, and 2b-were also present. In contrast, HCV infection in mainland China was confined to genotypes 1b and 2a. Thus, we found a greater diversity of HCV genotypes in Hong Kong than in mainland China.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:16:37