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Titolo:
IS THERE A RATIONALE FOR IRON SUPPLEMENTATION IN THE TREATMENT OF AKATHISIA - A REVIEW OF THE EVIDENCE
Autore:
GOLD R; LENOX RH;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT PSYCHIAT GAINESVILLE FL 32611 UNIV FLORIDA,COLL MED,DEPT PSYCHIAT GAINESVILLE FL 32611 UNIV VERMONT,COLL MED,DEPT PSYCHIAT BURLINGTON VT 00000
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 10, volume: 56, anno: 1995,
pagine: 476 - 483
SICI:
0160-6689(1995)56:10<476:ITARFI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW SERUM IRON; DOPAMINE-D2 RECEPTOR SUPERSENSITIVITY; NEUROLEPTIC-INDUCED AKATHISIA; BRAIN IRON; MOVEMENT-DISORDERS; TARDIVE-DYSKINESIA; PARKINSONS-DISEASE; RISK; DESFERRIOXAMINE; HEMOCHROMATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
R. Gold e R.H. Lenox, "IS THERE A RATIONALE FOR IRON SUPPLEMENTATION IN THE TREATMENT OF AKATHISIA - A REVIEW OF THE EVIDENCE", The Journal of clinical psychiatry, 56(10), 1995, pp. 476-483

Abstract

Background: An association found between akathisia and iron deficiency led to the suggestion that iron supplementation might be a useful therapeutic intervention for patients with akathisia. There is, however,a body of literature on the abnormal deposition of iron in the brain in several degenerative diseases like Hallervorden-Spatz syndrome, Parkinson's disease, and Alzheimer's disease. Given the ability of neuroleptics to chelate iron and promote its deposition in the brain, we questioned whether peripheral measures of iron are an accurate reflectionof central iron levels and thus whether there was a rationale for iron supplementation in akathisia. Method: A MEDLINE search for literature relating to iron and akathisia, tardive dyskinesia, and Parkinson's disease was carried out and critically reviewed.Results: Evidence is presented for the ability of neuroleptics to chelate iron, mobilize it from peripheral stores, and deposit it in the basal ganglia. The effect of iron on dopaminergic receptor activity in brain and the potentialrole of iron in degenerative and neuroleptic-induced movement disorders are reviewed. The preponderance of the evidence shows a relationship between iron excess in the basal ganglia and the movement disorders. We found no studies that have examined the regulation of central levels of iron in patients with akathisia. Conclusion: The rationale for iron supplementation in the treatment of akathisia is relatively weak, and there are potentially adverse long-term consequences as outlined in our review. More research is required to directly measure the level of iron in the brain of patients with akathisia, e.g., using magnetic resonance imaging, before such therapeutic intervention can be recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:28:33