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Titolo:
NITRIC-OXIDE IS INVOLVED IN THE ACTH-INDUCED BEHAVIORAL SYNDROME
Autore:
POGGIOLI R; BENELLI A; ARLETTI R; CAVAZZUTI E; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
Peptides
fascicolo: 7, volume: 16, anno: 1995,
pagine: 1263 - 1268
SICI:
0196-9781(1995)16:7<1263:NIIITA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; RATS; PEPTIDES; MSH;
Keywords:
ACTH; NITRIC OXIDE; STRETCHING; YAWNING; PENILE ERECTION; GROOMING; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Poggioli et al., "NITRIC-OXIDE IS INVOLVED IN THE ACTH-INDUCED BEHAVIORAL SYNDROME", Peptides, 16(7), 1995, pp. 1263-1268

Abstract

In many animal species, the ICV injection of ACTH and of several shorter sequences of the ACTH molecule (melanocortin peptides) induces a peculiar behavioral syndrome mainly characterized by excessive groomingand by repeated acts of stretching and yawning. in adult males, spontaneous penile erections with ejaculation are also induced. We have studied the effect of NO synthase inhibition on this behavioral syndrome. The IP injection of the NO synthase inhibitor L-N-G-nitroarginine methyl ester (NAME) significantly prevented-at the doses of 50 and 100 mg/kg-all the behavioral symptoms induced by the ICV administration of ACTH(1-24) (4 mu g/rat). On the other hand, the ICV injection of NAME (up to 300 mu g/rat) had no influence on the ACTH-induced excessive grooming and stretching, while significantly inhibited the display of yawnings and penile erections. These data indicate that brain NO synthaseis involved in the mechanism of ACTH-induced yawning and penile erections, whereas peripheral NO synthase is involved in the induction of stretching and grooming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:35:12