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Titolo:
EFFECTS OF LIDOCAINE INJECTIONS INTO THE LATERAL PARABRACHIAL NUCLEUSON DIPSOGENIC AND PRESSER RESPONSES TO CENTRAL ANGIOTENSIN-II IN RATS
Autore:
MENANI JV; BELTZ TG; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PSYCHOL IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brain research
fascicolo: 2, volume: 695, anno: 1995,
pagine: 250 - 252
SICI:
0006-8993(1995)695:2<250:EOLIIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-PRESSURE; DRINKING; NEURONS; LESIONS;
Keywords:
LATERAL PARABRACHIAL NUCLEUS; ANGIOTENSIN II; WATER INTAKE; ARTERIAL PRESSURE; THIRST; LOCAL ANESTHETIC;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Menani et al., "EFFECTS OF LIDOCAINE INJECTIONS INTO THE LATERAL PARABRACHIAL NUCLEUSON DIPSOGENIC AND PRESSER RESPONSES TO CENTRAL ANGIOTENSIN-II IN RATS", Brain research, 695(2), 1995, pp. 250-252

Abstract

This study investigated the effects of bilateral injections of the local anesthetic, lidocaine, into the lateral parabrachial nucleus (LPBN) on the dipsogenic and presser responses induced by intracerebroventricular (i.c.v.) injection of angiotensin II (ANG II). Centrally injected ANG II (50 ng/l mu l) induced water intake (10.2 +/- 0.8 ml/h) and presser responses (22 +/- 1 mmHg). Prior bilateral injection of 10% lidocaine (200 nl) into the LPBN increased the water intake (14.2 +/- 1.4 ml/h), but did not change the presser response (17 +/- 1 mmHg) to i.c.v. ANG II. Lidocaine alone injected into the LPBN also induced a presser response (23 +/- 3 mmHg). These results showing that bilateral LPBN injection of lidocaine increase water intake induced by i.c.v. ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II. These results also provide evidence that it is feasible to reversibly anesthetize this brain area to facilitate fluid-related ingestive behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:02:04