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Titolo:
CHANGES IN EXPRESSION OF PUTATIVE ANTIGENS ENCODED BY PIGMENT GENES IN MOUSE MELANOMAS AT DIFFERENT STAGES OF MALIGNANT PROGRESSION
Autore:
ORLOW SJ; HEARING VJ; SAKAI C; URABE K; ZHOU BK; SILVERS WK; MINTZ B;
Indirizzi:
FOX CHASE CANC CTR,INST CANC RES,7701 BURHOLME AVE PHILADELPHIA PA 19111 FOX CHASE CANC CTR,INST CANC RES PHILADELPHIA PA 19111 NYU,SCH MED,RONALD O PERELMAN DEPT DERMATOL NEW YORK NY 10016 NYU,SCH MED,DEPT CELL BIOL NEW YORK NY 10016 NCI,CELL BIOL LAB BETHESDA MD 20892 FOX CHASE CANC CTR,INST CANC RES PHILADELPHIA PA 19111
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 92, anno: 1995,
pagine: 10152 - 10156
SICI:
0027-8424(1995)92:22<10152:CIEOPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINASE-RELATED PROTEIN-1; TRANSGENIC MICE; MELANIN BIOSYNTHESIS; SKIN MELANOMA; MELANOCYTES; DOPACHROME; SEQUENCE; LOCUS; TRP-2; CDNA;
Keywords:
ALBINO LOCUS; BROWN LOCUS; SLATY LOCUS; SILVER LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Orlow et al., "CHANGES IN EXPRESSION OF PUTATIVE ANTIGENS ENCODED BY PIGMENT GENES IN MOUSE MELANOMAS AT DIFFERENT STAGES OF MALIGNANT PROGRESSION", Proceedings of the National Academy of Sciences of the United Statesof America, 92(22), 1995, pp. 10152-10156

Abstract

Cutaneous melanomas of Tyr-SV40E transgenic mice (mice whose transgene consists of the tyrosinase promotor fused to the coding regions of simian virus 40 early genes) strikingly resemble human melanomas in their development and progression. Unlike human melanomas, the mouse tumors all arise in genetically identical individuals, thereby better enabling expression of specific genes to be characterized in relation to advancing malignancy. The products of pigment genes are of particular interest because peptides derived from these proteins have been reported to function as autoantigens with immunotherapeutic potential in somemelanoma patients. However, the diminished pigmentation characteristic of many advanced melanomas raises the possibility that some of the relevant products may no longer be expressed in the most malignant cells. We have therefore investigated the contributions of several pigmentgenes in melanotic vs, relatively amelanotic components of primary and metastatic mouse melanomas. The analyses reveal marked differences within and among tumors in levels of mRNAs and proteins encoded by the wild-type alleles at the albino, brown, slaty, and silver loci. Tyrosinase (the protein encoded by the albino locus) was most often either absent or undetectable as melanization declined. The protein encoded bythe slaty locus (tyrosinase-related protein 2) was the only one of those tested that was clearly present in all the tumor samples. These results suggest that sole reliance on targeting tyrosinase-based antigens might selectively favor survival of more malignant cells, whereas targeting the ensemble of the antigens tested might contribute toward a more inclusive and effective antimelanoma strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:46:50