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Titolo:
THE ENDOTHELIN RECEPTOR PROFILE IN L6 MYOTUBES
Autore:
FEKETE Z; YANG XY; KIMURA M; AVIV A;
Indirizzi:
UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,HYPERTENS RES CTR,ROOM F-464,MSB,185 S ORANGE AVE NEWARK NJ 07103 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,HYPERTENS RES CTR NEWARK NJ 07103
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 275, anno: 1995,
pagine: 215 - 218
SICI:
0022-3565(1995)275:1<215:TERPIL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS; CLONING; FAMILY; ANTAGONIST; IRL-1620; PEPTIDES; BINDING; ETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
Z. Fekete et al., "THE ENDOTHELIN RECEPTOR PROFILE IN L6 MYOTUBES", The Journal of pharmacology and experimental therapeutics, 275(1), 1995, pp. 215-218

Abstract

In this study we characterized the endothelin (ET) receptors of cultured L6 myotubes in order to gain a further insight into the mechanism of the ET effect on skeletal muscle cells, Displacements of I-125-ET-1by unlabeled ET-1, ET-2 and ET-3 revealed receptors with a high affinity (K-d < 1 nmol/l) to ET-1 and ET-2 and a low affinity (K-d > 100 nmol/l) to ET-3, which suggested the presence of primarily ET(A) receptors on L6 myotubes. These findings were complemented by displacement binding kinetics, in which the ET(A) receptor antagonist JKC-301 was used. Moreover, the ET-1-evoked increase in the cytosolic free Ca was blocked by JKC-301 but not by the ET(B) receptor antagonist IRL-1038. Collectively, these findings indicate that the ET-mediated response in cultured skeletal muscle cells is through the ET(A) receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:50:43