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Titolo:
EFFECTS OF PINACIDIL ON ARTERIAL AND VENOUS RESISTANCES AND MEAN CIRCULATORY FILLING PRESSURE IN RATS
Autore:
WAITE RP; LIM SL; PANG CCY;
Indirizzi:
UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL VANCOUVER BC V6T 1Z3 CANADA UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT VANCOUVER BCV6T 1Z3 CANADA
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 116, anno: 1995,
pagine: 2322 - 2326
SICI:
0007-1188(1995)116:4<2322:EOPOAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM-CHANNEL OPENERS; CONSCIOUS RATS; VASODILATOR DRUGS; TONE; ANTAGONISTS; VASOPRESSIN; INVITRO; MUSCLE;
Keywords:
PINACIDIL; K CHANNEL OPENERS; MEAN CIRCULATORY FILLING PRESSURE (MCFP); CARDIAC OUTPUT, TOTAL PERIPHERAL RESISTANCE, VENOUS RESISTANCE,VENOUS COMPLIANCE; CAPACITANCE VESSELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Waite et al., "EFFECTS OF PINACIDIL ON ARTERIAL AND VENOUS RESISTANCES AND MEAN CIRCULATORY FILLING PRESSURE IN RATS", British Journal of Pharmacology, 116(4), 1995, pp. 2322-2326

Abstract

1 The effects of the potassium channel opener, pinacidil, on mean arterial pressure (MAP), mean circulatory filling pressure (MCFP), total peripheral resistance (TPR), cardiac output (GO) and resistance to venous return (RV) were studied in rats. 2 In pentobarbitone-anaesthetized rats given mecamylamine (ganglionic blocker, 3.7 mu g kg(-1)) and noradrenaline (1.5 mu g kg(-1) min(-1)) to suppress autonomic reflexes, pinacidil (60 and 180 mu g kg(-1) min(-1)), relative to the vehicle, reduced MAP and TPR in a dose-dependent manner but did not significantly alter CO, MCFP or R(nu). 3 Pinacidil (10-300 mu g kg(-1) min(-1)) caused similar increases in MCFP, an inverse index of venous compliance,and similar dose-dependent reductions in mean arterial pressure (MAP)in conscious, intact rats and rats infused with the ganglionic blocker, hexamethonium (150 mu g kg(-1) min(-1)). In rats with vasomotor tone elevated by the infusion of noradrenaline (1.5 mu g kg(-1) min(-1)),pinacidil caused markedly greater depressor responses but did not significantly alter MCFP. 4 Our results show that pinacidil is an efficacious vasodilator of arterial resistance blood vessels but has little venodilator activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:18:26