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Titolo:
CENTRAL CARDIOVASCULAR EFFECTS OF ACETYLCHOLINE IN THE CONSCIOUS DOG
Autore:
BREFEL C; LAZARTIGUES E; TRAN MA; GAUQUELIN G; GEELEN G; GHARIB C; MONTASTRUC JL; MONTASTRUC P; RASCOL O;
Indirizzi:
FAC MED TOULOUSE,INSERM,U137,PHARMACOL MED & CLIN LAB,37 ALLEES JULESGUESDE F-31073 TOULOUSE FRANCE FAC MED TOULOUSE,INSERM,U317,PHARMACOL MED & CLIN LAB F-31073 TOULOUSE FRANCE FAC MED LYON,ENVIRONM PHYSIOL LAB LYON FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 116, anno: 1995,
pagine: 2175 - 2182
SICI:
0007-1188(1995)116:4<2175:CCEOAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-FACTOR; CHOLINERGIC RECEPTORS; ARGININE VASOPRESSIN; CEREBRAL-VENTRICLES; NERVOUS-SYSTEM; BLOOD-PRESSURE; BRAIN-STEM; RELEASE; PLASMA; RATS;
Keywords:
ACETYLCHOLINE; BLOOD PRESSURE; CENTRAL CHOLINERGIC SYSTEMS; MUSCARINIC RECEPTOR; VASOPRESSIN; CATECHOLAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
C. Brefel et al., "CENTRAL CARDIOVASCULAR EFFECTS OF ACETYLCHOLINE IN THE CONSCIOUS DOG", British Journal of Pharmacology, 116(4), 1995, pp. 2175-2182

Abstract

1 The effects of central cholinomimetic drugs on cardiovascular and vasoactive hormonal responses (blood pressure, heart rate, catecholamines, vasopressin, atrial natriuretic factor, neuropeptide Y plasma levels and plasma renin activity) were investigated in conscious Beagle dogs. For this purpose a catheter was chronically implanted into each dog's cisterna magna to allow repeated central injections in the awake animals. 2 Intracisternal acetylcholine (20 mu g kg(-1)) significantly increased systolic and diastolic blood pressure. These changes were accompanied by an initial short term tachycardia followed by a long lasting bradycardia. Intracisternal acetylcholine also increased noradrenaline, adrenaline and vasopressin plasma levels, decreased plasma reninactivity but did not modify plasma levels of neuropeptide Y and atrial natriuretic factor. 3 The effects of acetylcholine were completely abolished by pretreatment with intracisternal injection of the muscarinic antagonist, atropine (5 mu g kg(-1)) but not by the intracisternal injection of the nicotinic antagonist, mecamylamine (25 mu g kg(-1)). 4 The present results demonstrate that there are qualitative and quantitative differences between the central cardiovascular effects of acetylcholine in conscious dogs compared to what we previously reported, using a comparable protocol, in anaesthetized dogs. Under both conditions, we observed a central cholinergically mediated increase in blood pressure secondary to an increase in sympathetic tone and vasopressin release but these responses were shorter (less than 10 min) in the conscious dogs than in anaesthetized dogs (more than 10 min). Moreover, wedetected in the response to the central cholinergic stimulation in the conscious dogs a significant increase in plasma adrenaline levels and biphasic changes in heart rate which were not described previously in the anaesthetized dog.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:22:05